摘要
目的了解本院2006-2009年临床分离的阴沟肠杆菌的感染分布和耐药趋势特点,为临床合理应用抗生素提供依据。方法用MicroScanWalkAway40全自动细菌分析系统对临床分离的阴沟肠杆菌进行鉴定和药敏试验,并分析结果。结果 207株阴沟肠杆菌主要分布在呼吸科及ICU;标本的主要来源为痰及咽拭子(75.36%);药敏试验结果显示,阴沟肠杆菌对亚胺培南、阿米卡星敏感性最高,对氨苄西林、阿莫西林/克拉维酸、头孢唑啉及头孢西丁的耐药性最严重,耐药率均>80%。结论阴沟肠杆菌对β-内酰胺类抗生素耐药形势不容乐观,临床抗感染治疗应以分离菌株的体外抗菌药物敏感性为参考,同时注意分离菌株的流行趋势,合理选用抗生素,避免诱导性耐药的产生。
Objective To investigate the distribution and drug-resistance characteristic of Enterobacter cloacae isolated from Beijing University Shenzhen Hospital from 2006 to 2009,in order to provide evidence for using antibiotics reasonably.Method E.cloacae strains were isolated,and the bacterial identification and antibiotic susceptibility testing of the strains were carried out using MicroScan WalkAway 40 system.Results From 20062009,207 strains of E.cloacae were isolated.The strains distributed mainly in Department of Respiratory Medicine and ICU.Sputum and pharynx swabs were the main source of the strains（75.36%）.The strains of E.cloacae were most sensitive to imipenem and amikacin.The resistance rates of E.cloacae to ampicillin,amox /clav,cefoxitin and cefazolin were highest（〉80%）.Conclusions E.cloacae is highly resistant to β-lactam antibiotics.Treatment of E.cloacae infection should be based on the results of susceptibility test in vitro.We should pay attention to the epidemic trends of the isolates strains,and use antibiotics reasonably,to avoid inducing drug resistance.
出处
《热带医学杂志》
CAS
2010年第6期704-706,共3页
Journal of Tropical Medicine
关键词
阴沟肠杆菌
耐药性
抗生素
Enterobacter cloacae
drug resistance
antibiotics
