摘要
目的探讨2种药流方法终止8～14周妊娠的临床效果。方法将要求终止妊娠的8．14周正常早孕女性135例，随机分成两组：复方组67例，晨服复方米非司酮1片／24h02次（总量：米非司酮60mg，双炔失碳酯10mg），首次服药后48h加服米索前列醇0．6mg，每隔4小时阴道内放置米索前列醇0．4mg，米索前列醇最多一天不超过9片（1．8mg）；单方组68例，一次顿服米非司酮150mg，米索前列醇用法同复方组。用药后观察患者的不良反应、阴道开始出血情况、腹痛情况、胎儿娩出距首次阴道塞药时间、胎儿娩出时阴道出血量、米索前列醇用量，是否需要清宫，同时随访流产后15天、45天，观察患者阴道出血持续时间、出血量的多少及月经转经时间。结果复方组在流产成功率、完全流产率优于单方组，但在米索前列醇用量及妊振物排出时间、流产后阴道流血持续时间、出血量及下次月经转经时间上两组之间差异无显著性（P〉0．05）。结论复方米非司酮配伍米索前列醇能安全有效终止8—14周正常妊振，疗效较好，流产成功率较满意。具有米非司酮剂量小，服药简便等优点。
Objective To explore the efficacy of two medical abortion approachs for terminating 8-14 weeks＇ gestation, Methods 135 pregnant women at 8 to 14 weeks was requested pregnancy termina- tion were randomly divided into 2 groups： compound mifepristone group and mifepristone group. In the former group, 67 women received oral compound mifepristone （mifepristone 60 mg and anordrin 10 mg） one tablet twice on the first day, and then oral misoprostol of 0.6 mg 48 hours later, with vaginal misoprostol of 0.4mg every 4 hours （total dosage of misoprostol 〈 1.8 mg/day）. In mifepristone group, 68 received oral mifepristone of 150mg once, and then the same use of misoprostol as the former group. Adverse reactions, vaginal bleeding, cramping, time from vaginal medication use to fetal delivery, bleeding volume during fetal dilivery, dosage of mifepristone, and application of D＆C were noted. The women were followed up on days 15 and 45 to record duration and volume of vaginal bleeding and time to menstrual recovery. Results The success rate of abortion and rate of completed abortion were higher in compound mifepristone group than in mifepristone group. There were no significant differences in dosage of misoprostol, the time of discharging embro and placenta were （ 250.9± 174.15 ） minutes and （ 253.7 ± 148.70 ） minutes respectively.There were no significant differences （P〉0.05）. Conelutions Compound mifepristone combined with misoprostol can terminate 8-12 weeks＇s gestation safely and effectively. It is simple and has a better efficacy with a ideal success rate of abortion and less dosage of mifepristone .
出处
《国际医药卫生导报》
2010年第13期1617-1620,共4页
International Medicine and Health Guidance News
