摘要
目的观察１０－羟基喜树碱腔内注射治疗恶性胸（腹）水的疗效。方法腔内灌注１０－羟基喜树碱治疗２７例恶性胸（腹）腔积液患者。结果ＣＲ９例，ＰＲ１３例，ＮＲ５例。有效率８１．５％（２２／２７）。此局部治疗耐受性好，无明显毒副反应。结论与其它胸（腹）水治疗方法比较，该方法具有疗效高、毒副反应低的特点。
Objective To evaluate the effect of 10-HCPT instillation pleural or abdominal cavity in the management of malignant pleural effusion or ascites. Methods Twenty-seven cases with malignant pleural effusion or ascites were treated by instillating 10-HCPT into pleural or abdominal cavity. Results CR was achieved in 9 cases ,PR in 13 cases, NR in 5 cases. The overall response rate was 81.5%(22/27).This local regimen was well tolerated without any undesired side effects. Conclusion This approach of therapy was superior to other management modlities in terms of higher efficacy and lower toxicity.
关键词
10-羟基喜树碱
局部治疗
胸腹水
肿瘤
疗效
hydroxyl camptothecine Malignant pleural effusion or ascites Local regimen
