摘要
目的探讨抑癌基因在前列腺癌组织中的表达及临床意义。方法应用免疫组织化学方法，检测２５例前列腺癌中ｐ５３和ｐ１６基因蛋白产物的表达。结果ｐ５３蛋白阳性率为３２％（８／２５），明显高于良性前列腺增生（Ｐ＜０．０５），并在低分化肿瘤中表达高（Ｐ＝０．０４０３）；在临床分期Ⅲ～Ⅳ期癌中表达升高（Ｐ＜０．０５）。ｐ１６的失活率４４％（１１／２５），也是低分化组高于高分化组（Ｐ＜０．０５）。并发现４例低分化癌中有ｐ５３和ｐ１６共同异常。结论ｐ５３和ｐ１６基因的异常表达均与前列腺癌的形成和恶性程度有关，但两者之间是否具有协同作用尚待进一步证明。
Objective To study the expression and significance of antioncogene p53 and p16 in prostatic adenocarcinoma. Methods Protein products of p53 and p16 were detected in 25 patients with prostatic adenocarcinoma by immunohistochemical method. Results P53 protein cxpression was higher in low differentiated group than that in high middlegroup(P<0.05),higher in late clinical stages than in early, there was no mutation in 15 cases with BPH.P16 protein deletion rate was 44%(11/25), was higher in low differentiated group than that in well differentiated group. (P< 0.05 ).4 cases with low diferentiated carcinoma showed expression of p53 and deletion of p16.Conclusion Abnormal p53 and p16 gene was correlated with the malignancy of prostatic adenocarcinoma, whether p53 and p16 gene were cooperated needs to be further studied.
