摘要
目的了解新疆乌鲁木齐市2003-2009年儿童志贺菌属感染情况及耐药性,掌握细菌性痢疾的流行与分布。方法收集2003-2009年3所医院收治的腹泻儿童的粪便标本,采用全自动细菌鉴定仪鉴定分离菌株,血清凝集法进行分型,采用抗生素纸片扩散法(K-B)检测菌株对抗生素的耐药性,采用世界耐药监测网软件(WHONET5.4)进行统计分析。结果乌鲁木齐市儿童中志贺菌属主要分布在0～3岁,占54.06%;时间以5-10月居多,占85%;志贺菌属的菌型分布以B群福氏志贺菌为主,其次为D群宋内志贺菌,分别为276,27株;4群志贺菌对青霉素类抗生素耐药率为50%～100%,对三代头孢菌素和喹诺酮类耐药率为0～62.6%,对亚胺培南100%敏感。结论乌鲁木齐市儿童菌痢流行型为福氏志贺菌;菌群耐药性存在明显地区差别。
Objective To analyze strain types and antibiotic resistance of Shigella shigae isolated in children of Urumqi and to know the epidemic and distribution of bacillary dysentery in the children.Methods Samples of child diarrhea patients in 2003 to 2009 were collected.Bacterial strains were identified with automatic bacterial critical instrument.The strain types were identified with serological test and the drug-susceptibility was detected with antibiotic slip difusion methods.WHONET5.4 was used in statistical analysis.Results Most of the children with shigellosis were at age of zero to three years（54.06%）.Among all shigellosis,85% occured from May to October.Most of strain types were Shigella Flexner and Shigella sonnei.Four groups of Shigella showed highly resistance to penicillium（50%-100%）and low resistance to third generation cephalosporin and fluoroquinolones（0-62.6%）.But all of the strains sensitive to imipenem.Conclusion Shigella Flexner is a dominant epidemic strain in children with dysentary in Urumqi and different strains have different antibiotic resistance.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2010年第7期897-898,共2页
Chinese Journal of Public Health
基金
乌鲁木齐市人才工程科研基金(P08131003)
关键词
儿童
志贺菌
耐药性
细菌性痢疾
child
Shigella
antibiotic resistance
bacillary dysentery
