摘要
以具有抗炎镇痛活性的２Ｈ１，２二氢１吡咯哩嗪酮（Ⅰ，下称吡哩酮）为先导化合物，设计合成了１３个未见文献报道的氨甲基吡咯哩嗪酮类化合物．发现了一种合成５氨甲基吡哩酮类衍生物的方法．对其中８个化合物进行抗炎镇痛作用实验，发现大部分化合物具有一定的抗炎镇痛作用。
A synthetic method of 5 aminomethyl 2 H 1,2 dihydro 1 pyrrolizinone was developed with a new procedure of the Mannich reaction,and thirteen of the derivative of the kind were designed and synthesized.The analgesic and antiinflammatory effects of some of the compounds synthesized were tested in mice.The results showed that most of the compounds had antiinflammatory and analgesic activities.
出处
《中国药物化学杂志》
CAS
CSCD
1999年第1期16-20,共5页
Chinese Journal of Medicinal Chemistry
关键词
氨甲基吡哩酮
抗炎镇痛
合成
aminomethyl pyrrolizinone
antiinflammatory and analgesic effects
synthesis
