痰湿型多囊卵巢综合征临床及内分泌特征分析被引量：13

Analysis of Clinical and Endocrinal Characteristics of Polycystic Ovary Syndrome with Phlegm-dampness

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摘要目的:探讨多囊卵巢综合征痰湿证临床及内分泌特征性指标,从而为多囊卵巢综合征的中医规范化诊治提供依据。方法:以45例正常育龄妇女为对照组,135例PCOS患者分为两组:非痰湿组、痰湿组,其中非痰湿组85例,痰湿组50例,化学发光法测定血清性激素水平及DHEA-S、FPG、FINS、SHBG水平。分别比较3组初潮年龄、月经周期、BMI、腰围、SBP、DBP等临床指标的差异性,3组血清性激素水平及DHEA-S、SHBG、FPG、FINS、HOMA-IR及FTI水平的差异性。结果:(1)各组间临床特征比较:月经周期PCOS两组与对照组比较均有显著性差异(P<0.05);BMI、腰围PCOS痰湿组与对照组及非痰湿组比较均有显著性差异(P<0.05)。(2)各组间性激素及DHEA-S的比较:LH、T值PCOS两组与对照组比较均有显著性差异(P<0.05);DHEA-S值PCOS非痰湿组与对照组比较有显著性差异(P<0.05),PCOS痰湿组与对照组比较有极显著性差异(P<0.01),PCOS痰湿组与PCOS非痰湿组比较也有显著性差异(P<0.05)。(3)各组间胰岛素抵抗相关参数及SHBG、FTI的比较:FINS、HOMA-IR、SHBG、FTI值PCOS痰湿组与对照组比较有极显著性差异(P<0.01),PCOS痰湿组与PCOS非痰湿组比较也有显著性差异(P<0.05)。结论:多囊卵巢综合征痰湿证在BMI、腰围、DHEA-S、SHBG、FPG、FINS、HOMA-IR及FTI等水平具有特征性表达,胰岛素抵抗相关指标可以作为其客观诊断依据之一。 Objective：To explore the characteristic index of PCOS patients with phlegm-dampness in order to give further basis on standardized diagnosis and treatment of PCOS.Methods：45 normal reproductive-aged women as controls,and 135 PCOS patients were divided into two groups：phlegmdampness group and non phlegm-dampness group.Serum sex hormone,as well as DHEA-S,FPG,FINS,SHBG levels were measured by Chemiluminescence.Indeics above and other parameters（menstrual cycle,BMI,waist size,Homa-IR,FTI etc were compared among groups.Results：（1） Clinical characteristics：menstrual cycle：PCOS groupscontrol;BMI,waist size：phlegm-dampness PCOS groupcontrol,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .（2） Sex hormone and DHEA-S：LH,T levels：PCOS groupscontrol,DHEA-S level：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .（3） IR related parameters：FINS,HOMAIR,FTI：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegm-dampness PCOS groupnon phlegmdampness group（P〈0.05） ;SHBG level：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .Conclusions：There were characteristic expression on BMI,waist size,DHEA-S,SHBG,FPG,FINS,HOMA-IR and FTI levels in phlegmdampness PCOS patients,they might be one of objective diagnosis basis of phlegm-dampness PCOS patients.

作者张宁刘家义

机构地区山东中医药大学

出处《辽宁中医药大学学报》 CAS 2010年第7期27-29,共3页 Journal of Liaoning University of Traditional Chinese Medicine

基金教育部博士点基金课题(20093731110001)

关键词多囊卵巢综合征痰湿胰岛素抵抗性激素结合球蛋白游离睾酮指数 Polycystic ovary syndrome phlegm-dampness insulin resistance sex hormone-binding globulin free testosterone index

分类号 R711.75 [医药卫生—妇产科学]

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