摘要
谷氨酰胺（ｇｌｕｔａｍｉｎｅ，Ｇｌｎ）是合成体内抗氧化剂—还原型谷胱甘肽（ｒｅｄｕｃｅｄｇｌｕｔａｔｈｉｏｎｅ，ＧＳＨ）的前体物质。研究表明，手术创伤后出现免疫抑制的同时常伴有体内Ｇｌｎ含量的显著降低。本实验旨在评价补充Ｇｌｎ能否维持胃肠手术患者外周...
AIM and METHODS: To investigate the relationship between immunologic function and hormone level in cancer patient, we studied the plasma testosterone and corticosteroids levels and mitogenesis of T lymphocyte and IL-2 activities of patients with hepatocarcinoma, carcinoma of stomach and intestine as well as controls by using bioassay technique. RESULTS: (1)Compared with the control group, the testosterone level of all cancer groups decreased significantly, and plasma corticosteroids levels were much higher. The two indexes present negative correlation. The mitogenesis of T lymphocytes and IL-2 activity decreased remarkably in comparison with controls. The above indexes had no significant difference among all the cancer groups. (2) The plasma corticosteroids content presented remarkable negative correlation with mitogenesis of T lymphocytes and IL-2 activities. CONCLUSION: T lymphocyte functions of patients were severely depressed, it may be correlated with changes of plasma testosterone and corticosteroids levels.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第2期136-136,146,共2页
Chinese Journal of Pathophysiology
