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酵母蛋白质相互作用网络中Hub蛋白分类及作用规律的研究

Study on Hub Protein Classification and Interaction Law in Protein-Protein Interaction Network of Saccharomyces cerevisiae
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摘要 在蛋白质相互作用网络层面研究蛋白质的生物学功能已成为系统生物学的一项重要工作。Hub蛋白是指蛋白质相互作用网络中连接数较高的蛋白,在生命活动中行使着极为重要的功能。然而仅仅依靠连接数并不能准确反映出蛋白质在生物学网络中的真实地位,连接数相近的Hub蛋白在生物网络中发挥的作用未必同等重要。依据Gene ontology数据库中的生物学注释信息,使用X均值聚类法将Hub蛋白分为系统、组分和过程Hub三类;对这三类Hub蛋白构成的子网络进行研究,发现系统Hub和非Hub蛋白子网络分布均匀,而组分Hub和过程Hub的子网络有明显的模块性;进一步引进描述各类Hub蛋白之间相互作用倾向性的参数并对其进行分析,结果表明:三类Hub蛋白之间(包括同一类Hub蛋白间)、非Hub蛋白与Hub蛋白间相互作用的倾向性强烈,而反过来,三类Hub蛋白与非Hub蛋白之间、非Hub蛋白内部相互作用的倾向性很弱。 It is important to study biological function of proteins based on protein-protein network in system biology. Hub protein, as protein with high connected degree, plays an important role in biological processes. However,connect degree can not describe protein function in biological network, since Hub proteins with equally or similar connect degree are usually not equal important. Using X-means clustering, Hub proteins were classified into three categories based on biological annotation information in Gene Ontology. Results indicate that the distribution of sub-networks of system Hub and non-Hub proteins is uniform, that of process Hub and component Hub proteins are obviously modular. The parameter, protein class interaction bias （PCIB）, was introduced to describe interaction bias between or within Hub proteins and non-Hub proteins. Results showed that interaction bias among Hub proteins, between non-Hub proteins and hub proteins were strong, PCIB values among non-Hub proteins or between Hub and non-Hub proteins are very small.
作者 秦笙 蔡禄
机构地区 内蒙古科技大学生物工程与技术研究所 内蒙古科技大学数理与生物工程学院
出处 《生物物理学报》 CAS CSCD 北大核心 2010年第6期488-496,共9页 Acta Biophysica Sinica
基金 国家自然科学基金项目(60761001)~~
关键词 蛋白质相互作用网络 Hub蛋白 GENE Ontology注释 分类 Protein-protein interaction network Hub protein Gene Ontology annotation Classification
分类号 Q61 [生物学—生物物理学]
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参考文献18

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生物物理学报
2010年 第6期

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