摘要
目的：探讨使用大剂量干扰素（ＩＦＮα）治疗慢性丙型肝炎（ＣＡＨ）的效果。方法：使用大剂量ＩＦＮα，每天６００万Ｕ，连续投药３周，以后每周３次间断投药２１周，共计２４周，治疗ＣＡＨ５０例。观察治疗前后血清ＨＣＶＲＮＡ与ＡＬＴ的变化，以此作为ＩＦＮ疗效的判定指标。结果：ＩＦＮ治疗ＣＡＨ有效率为６８％，停药６个月后有３４％复发。结论：ＩＦＮ的疗效与ＣＡＨ的基因亚型有关（Ⅲ型疗效显著，Ⅱ型较差），与ＩＦＮ的剂量无明显关系。
Objective:To discuss the clinical effect of interferon(IFN α) in the treatment of chronic active type C hepatitis(CAH).Methods:Fifty patients was treated by large dose IFN α,6 million units daily for 3 weeks , afterwards 3 times eachweek for 21 weeks.It was the determining index to observe the changes of serum HCV RNA and titers of ALT before and after IFN treatment.Results:The effective rate of IFN in the treatment of CAH was 68%,34% of the cases recurred by the time of 6 months after the treatment of IFN. Conclusions: The effect of IFN is related to gene subtype of CAH(the 3 type effect is notable,the 2 type effect is not notable),but not to the therapy dose of IFN.
出处
《中国冶金工业医学杂志》
1999年第1期13-14,共2页
Chinese Medical Journal of Metallurgical industry
