摘要
【目的】探讨抗磷脂抗体（APL）阳性的先兆流产孕妇的血液流变学变化。【方法】选择APL阳性的先兆流产孕妇102例，其中54例既往无不良孕产史者为A组，48例有不良孕产史的抗磷脂综合征（APS）患者为B组。另选择50例APL阴性的正常孕妇为对照组（C组）。用血液粘度仪及动态血沉／压积测试仪测定三组孕妇的血液流变学指标。【结果]B组的全血粘度（Nb）包括高切及低切浓度、血浆粘度（Np）、红细胞压积（HCT）、红细胞聚集指数（VAI）和红细胞刚性指数（IR）均高于A、C两组，而红细胞变形指数（DI）低于A、C两组，差异比较均有统计学意义（P〈0．05）。A组的全血高切及低切粘度高于c组，差异有统计学意义（P〈0．05），其他血液流变学指标A、C两组比较无统计学意义（P〉0．05）。【结论】APL阳性先兆流产孕妇的血液粘度增高，其中APS孕妇的红细胞聚集性增加和变形能力减弱，可能与自然流产、死胎等不良妊娠结局相关。在APL阳性的先兆流产孕妇中常规进行血液流变学指标检测有助于预测妊娠并发症并予早期治疗。
[Objective]To study the changes of hemorheological parameters in threatened abortion women with antiphospholipid antibody（APL）. [Methods] A total of 102 threatened abortion women with APL were chosen. All of them were divided into Group A（ n =54） without bad pregnancy history and group B（ n =48） with antiphospholipid syndrome（APS） and bad pregnancy history. Fifty normal pregnant women with negative APL were selected as control group（group C）. Hemorheological parameters were measured in three groups by using blood viscometer and dynamic ESR/HCT. [Results]The values of whole blood viscosity（Nb） in high and low shear rate, plasma viscosity（Np）, hemotocrit（HCT）, erythrocyte aggregation index（VAI） and erythro eyte rigidity index（IR） in group B were significantly higher than those in group A and C（ P〈0.05）. The red blood cell deformability index（DI） in group B was markedly lower than that in group A and C（ P 〈0.05）. The whole blood viscosity in high and low shear rate in group A was remarkably higher that in group C（ P 〈 0. 05）. There was no significant difference in other hemorheological parameters between group A and C（P 〉 0.05）. [ConclusionlThe blood viscosity increases in the threatened abortion woman with positive APL. Simultaneously, erythrocyte aggregation increases and the deformation of red blood cell decreases in APS pregnant women, which may be correlated with adverse pregnancy outcomes such as spontaneous abortion and fetal death. Measuring the hemorheologieal parameters in threatened abortion women with positive APL is helpful for forecasting pregnant complications and giving the early treatment.
出处
《医学临床研究》
CAS
2010年第6期999-1001,共3页
Journal of Clinical Research
基金
[基金项目]湖南省卫生厅课题y02-035
2005099（C2005018）
关键词
流产
先兆
抗体
抗磷脂
血液流变学
abortion,threatened
antibodies,antiphospholipd
hemorheology
