摘要
目的和方法：应用显微电视录象设备和活体大鼠肠系膜微循环观察技术，观察胸导管淋巴液对重症失血性休克大鼠血压和微循环障碍的影响，以探讨淋巴液的抗休克作用及其机制。结果：淋巴液治疗组大鼠存活时间（７０３ｈ）显著高于白蛋白对照组（２０５ｈ）。治疗组输入胸导管淋巴液后血压显著回升，血液流态改善，有效地解除肠系膜细动、静脉和微淋巴管（ＭＬ）静态口径的病理性收缩，ＭＬ收缩分数、总收缩活性指数及淋巴管动力学指数恢复正常，而白蛋白对照组的微血管口径及三个ＭＬ收缩性指数仍处于休克时水平，且明显低于治疗组（Ｐ＜０．０１）。结论：淋巴液具有良好的抗休克作用。
Aim and Methods:To observe the effect of thoracic duct lymph on the blood pressure
and obstruction of microcirculation in rat with irreversible hemorrhagic shock by a microscope
with TV recorder and the technique of vital observation on mesenteric microcirculation in
rats.Results:The average survival time was obviously prolonged (7.03 h) in the thoracic duct
lymph treated group, and the lymph was able to make blood pressure in shock rise significantly
compared with albumin control group (2.05 h). After the administration of thoracic duct lymph in
the treated group, the pathological narrow and spasm of mesenteric micro vessles and micro
lymphatics(ML) in shock was removed apparently; the mesenteric micro vessles blood flow
condition and its speed were improved progressively, thus they return back to the normal
condition; ML contractile fraction,overall lymphatic contractile activity and lymphatic dynamics
restored.In albumin control group,the diameter in micro vessels and ML contractility were still
in lower level as in shock and ever lower than treated group. But there was no statistical
difference between two groups in ML spontaneous contraction frequency. Conclusion:Lymph
may improve the obatruction of microcirculation in shock and have better antagonistic role on
hemorrhagic shock.
出处
《中国应用生理学杂志》
CAS
CSCD
1999年第1期72-76,共5页
Chinese Journal of Applied Physiology
基金
国家自然科学基金
关键词
淋巴液
失血性休克
微循环
lymph
hemorrhagic shock
microcirculation
