摘要
目的和方法：实验选用ＳＤ大鼠戊四氮（ＰＴＺ）模型，结合电刺激或电解毁损丘脑网状核、丘脑接替核（丘脑腹后外侧核）、丘脑前核（丘脑前内侧核），并用蝇蕈醇、氯苯氨丁酸、３疏基丙酸等药物在丘脑网状核内微量注射或腹腔注射后观察棘慢波的变化。结果：电刺激丘脑网状核可增强癫痫小发作，毁损丘脑网状核可抑制癫痫小发作。
Ain and Methods:Model of PTZ induced epilepsy of absence type was used in this investigation. The spike wave (SW)pattern was monitored after electrostimulation or electrolytic destruction applied to reticular thalamic nucleus(Rt), ventral posterolateral thalamic nucleus(VPL), anteromedial thalamic nucleus(AM), and the effects of these stimulations or destructions on electroacupuncture (EA) were also observed after injection (i. p. ) or focal microinjection of muscimol, baclofen, 3 mercaptopropionic acid (3 MP). Results: Rt plays an important role in absence epilepsy, whereas the activity of GABA B receptor markedly deteriorated the process.
出处
《中国应用生理学杂志》
CAS
CSCD
1999年第1期59-61,共3页
Chinese Journal of Applied Physiology
