摘要
目的和方法：本文通过检测大鼠肝脏、股四头肌中ＧＳＨＰＸ、谷胱甘肽转硫酶（ＧＳＴ）、谷胱甘肽还原酶（ＧＲ）活性及脂质过氧化（ＬＰＯ）产物丙二醛（ＭＤＡ）的含量变化，观察耐力训练对大鼠机体产生内源性自由基及谷胱甘肽抗氧化系统酶活性的影响。结果：ＳＤ雄性大鼠经１１周跑台训练后，安静状态时肝脏中ＭＤＡ含量下降，ＧＳＨＰＸ、ＧＳＨ活性下降，股四头肌中ＧＳＨＰＸ、ＧＳＴ活性升高；９０ｍｉｎ定量负荷运动使大鼠肝脏中ＭＤＡ含量升高，ＧＳＨＰＸ、ＧＳＴ、ＧＲ活性均下降，但训练组ＧＳＨＰＸ、ＧＳＴ活性恢复较快。结论：大鼠经耐力训练后提高了谷胱甘肽抗氧化系统酶的抗氧化功能，表现了良好的运动适应性，且恢复较快。值得注意的是训练组大鼠ＧＲ活性在运动后恢复期存在下降趋势，其机理有待进一步研究。
Aim and Methods:To observe the effect of endurance training on activity of
glutathione antioxidant enzyme system the reactive oxygen intermedias by examining GSH P
X,GST,GR activity and MDA content. Results: GSH P X,GST activity and MDA content
decreased in rat liver,GSH P X, GST activity increased in rat quadriceps,but no changes of GR
activity at rest. After 90 minutes treadmill exercise,MDA content increased in rat liver and
Quadriceps,GSH P X,GST,GR activity decreased,less decreased in traind rat and GSH P X
recovered more rapidly in trained rat. Conclusion:The trained rat was better adaptable to
exercise It is unclear why GR activity decreased at 8 hours after exercise. GSH P X; GST;
GR; MDA; endurance training
出处
《中国应用生理学杂志》
CAS
CSCD
1999年第1期55-58,共4页
Chinese Journal of Applied Physiology
