摘要
阿尔茨海默病(Alzheimer's disease,AD)是老年痴呆症中最常见的类型,其发病机制十分复杂,β淀粉样蛋白(amyloid-β,Aβ)被认为是诱发AD发生和发展的关键因素。一般认为,细胞外Aβ沉积在AD的发病中发挥重要作用,但越来越多的证据表明细胞内Aβ也参与AD的发病过程。研究发现,细胞内Aβ沉积可导致线粒体损伤、内质网应激、钙失衡、氧化应激、细胞凋亡、突触障碍,并可影响细胞信号转导。
Alzheimer＇s disease（AD） is the most common pattern of senile dementia and its molecular pathogenesis is complicated.Amyloid-β peptides play a pivotal role in the pathogenesis of Alzheimer＇s disease.The deposition of extracellular Aβ has been suggested to be the cause of AD,but emerging evidence indicates that intracellular Aβ also plays a pathophysiologi-cal role in AD.Possible mechanisms have been suggested to account for the intracellular Aβ toxicity,including mitochondria dysfunction,endoplasmic reticulum stress,calcium dysregulation,oxidative stress,apoptosis,synaptic dysfunction and the inhibition of signaling pathway.
出处
《生命的化学》
CAS
CSCD
北大核心
2010年第3期425-428,共4页
Chemistry of Life
