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PD-1及其配体PD-L在HIV感染中的作用 被引量：3

Association between PD-1/PD-L and HIV infection
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摘要 共刺激信号不仅可以协助激活T细胞,而且可以通过负性共刺激信号下调免疫反应,从而精确地调节应答的程度和持续时间。以PD-1/PD-L为代表的负性共刺激途径,在免疫学的试验研究和临床免疫治疗中均有重要意义,近年来该途径被认为与移植排斥反应、自身免疫性疾病、肿瘤免疫逃逸,尤其是慢性病毒感染如艾滋病等疾病密切相关。本文主要介绍PD-1及其配体PD-L的结构、表达特性及其在HIV感染中的作用,探讨其在艾滋病病情发展中的作用机制和治疗方面的应用前景。 Costimulatory signal can not only assist T cell activation but also downregulate immune response through the negative signal programmed death-1（PD-1） and its ligands,PD-L1（also B7-H1） and PD-L2（also B7-DC） to regulate the extent and duration of response.The typical negative costimulatory signal pathway is involved in the mechanisms of trans-and auto-immune diseases,tumor immune evasion and chronic viral infection for example AIDS.This paper reviews the roles of PD-1 and its ligands in the development and treatment of HIV infection.
作者 史继静 刘朝奇
机构地区 三峡大学分子生物学研究所
出处 《生命的化学》 CAS CSCD 北大核心 2010年第3期397-400,共4页 Chemistry of Life
基金 2008年湖北省自然科学基金(No.ZRY1279)资助
关键词 PD-1 PD-1配体 HIV感染 PD-1 PD-L1 HIV infection
分类号 R392.11 [医药卫生—免疫学]
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参考文献21

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同被引文献31

  • 1Tao Shen,Jiajia Zheng,Chunhui Xu,et al. PD-1 expres- sion on peripheral CD8 + TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C pa- tients[J]. Virology Journal,2010,7(12) :310-318.
  • 2Chen J,Wang XM,Wu XJ,et al. Intrahepatic levels of PD-1/PD-L correlate with liver infl-ammation in chron- ic hepatitis B[J]. Infl amm Res, 2011,60(1 ) :47-53.
  • 3Zhang Wenjin, Peng Chuanhui, Wan Yunle, et al. Longi- tudinal fluctuations in PD1 and PD-L1 expression in association with changes in anti-viral immune response in chronic hepatitis B[J]. BMC Gastroenterol,2012,12(8): 109-119.
  • 4Feuth T,Arends JE,Fransen JH,et al. Complementary role of HCV and HIV in tactivation and exhaustion in T- cell HIV/HCV coinfection[J]. Plos One,2013,8(3) : 1-9.
  • 5Spahn J,Pierce RH,Crispe IN,et al. Ineffective CD8(+) T-Cell immunity to adeno virus can result in prolonged associated liver injury and fibrogenesis[J]. The American Journal of Pathology, 2011,179 (5) : 2370-2381.
  • 6Day CL,Kaufmann DE,Kiepiela P,et al.PD-1expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression[J].Nature,2006,443(719):350-354.
  • 7Jones RB,Ndhlovu LC,Barbour JD,et al.Tim-3expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1infection[J].J Exp Med,2008,205(12):2763-2779.
  • 8Rosignoli G,Lim CH,Bower M,et al.Programmed death(PD)-1molecule and its ligand PD-L1distribution among memory CD4and CD8Tcell subsets in human immunodeficiency virus-1-infected individuals[J].Clin Exp Immunol,2009,157(1):90-97.
  • 9Petrovas C,Casazza JP,Brenchley JM,et al.PD-1is a regulator of virus-specific CD8+T cell survival in HIV infection[J].J Exp Med,2006,203(10):2281-2292.
  • 10Sakhdari A,Mujib S,Vali B,et al.Tim-3negatively regulates cytotoxicity in exhausted CD8+T cells in HIV infection[J].PLoS One,2012,7(7):e40146.

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生命的化学
2010年 第3期

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