摘要
目的:观察复方苦参注射液联合术前放疗及手术治疗Ⅲ期食管癌的临床效果。方法:Ⅲ期食管癌162例,半随机分为实验组和对照组。实验组给予术前放疗40Gy/4周,休息2周后手术,放疗及手术后给予复方苦参注射液20mL·d-1;对照组分为单纯放疗60Gy组,及直接手术组。观察实验组放疗40Gy时、2周后术前与单纯放疗组40Gy、60Gy时放疗疗效、放疗副反应及与直接手术组的手术切除率、手术并发症及术后放疗病理反应程度。结果:术前放疗40Gy时及2周后放疗有效率,实验组为80.3%、85.2%,单纯放疗组40Gy、60Gy时为77.6%、83.7%,放疗副反应为11.5%与16.3%,两组根治切除率,手术并发症发生率无差异,手术疼痛程度减轻。术后食管肿瘤病理重度反应有27.9%。结论:术前放疗并手术方案联合复方苦参注射液,明显提高Ⅲ期食管癌放疗及手术的综合治疗效果。
OBJECTIVE：To evaluate the efficacy of compound flavescentis（Yanshu injection） in combination with pre-operative radiotherapy and surgery in treatment of clinic stage Ⅲ esophageal carcinoma.METHODS：162 patients with clinical stage Ⅲ esophageal cancer were randomized to two groups：experimental group received pre operative radiotherapy（DT40 Gy in 4 weeks） followed by surgery operated 2 weeks later and administration of compound Yanshu injection（20 mL·d-1）,wherease the control group subdivided into radiotherapy（DT60 Gy） alone group and surgery alone group.Radioactive response and side reactions were observed for the experimental group when the radiation was delivered at 40 Gy and at 2 weeks after completion of pre-operative radiotherapy and for radiotherapy alone group when the radiation was delivered at 40 Gy and 60 Gy,meanwhile,radical resection rate,operative-related complications and post-operative pathological reaction in patients undergoing surgery alone were observed.RESULTS：The effective radiotherapy response rates in the experimental group when the radiation was delivered at 40 Gy and at 2 weeks after completion of pre-operative radiotherapy were80.3% and 85.2%,respectively,as compared with 77.6% and 83.7%,respectively forradiotherapy alone group when the radiation was delivered at 40 Gy and 60 Gy.The incidences of side reaction induced by radiotherapy were11.5% and 16.3%,respectively.There were no significant differences in radical resection rate,operative-related complications between the two groups.27.9% presented withpost-operative severe pathological reaction.CONCLUSION：Addition of compound flavescentis injection greatly enhances the efficacy in patients with stage Ⅲ esophageal carcinoma treated with radiotherapy and surgery.
出处
《中国医院用药评价与分析》
2010年第6期542-544,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
复方苦参注射液
术前放疗
手术
食管癌
Compound flavescentis
Pre-operative radiotherapy
Surgery
Esophageal-carcinoma
