摘要
目的观察吡格列酮联合克罗米芬治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)的疗效。方法将44例患者随机分为单用克罗米芬组、单用吡格列酮组和联合用药组3组,测量患者体重并计算体重指数(BMI),测定患者血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、空腹血糖(FBG)及胰岛素(FBI)水平,自测基础体温(BBT)及B超监测排卵,并进行治疗前后的比较。结果联合用药组除FSH外,其他指标均获得明显改善。结论吡格列酮联合克罗米芬治疗PCOS较单用其中之一效果显著。
Objective To investigate the therapeutic effect of pioglitazone combined with chloramiphene in the treatment of polycystic ovary syndrome（PCOS）.Methods 44 cases between Jan.2008 and Dec.2009 were randomly divided into three groups including single-use chloramiphene,single-use pioglitazone and drug combination group.The patients＇body weights were measured to calculate the body mass indexes（BMI）.The levels of serum follicle stimulating hormone（FSH）,luteinizing hormone（LH）,testosterone（T）,fasting blood glucose（FBG）and fasting blood insulin（FBI）were measured.Self-measured basal body temperature（BBT）and ovulation monitored by ultrasound B were compared before and after treatment.Results All the indexes except FSH in the drug combination group showed obvious improvement.Conclusion Pioglitazone combined with chloramiphene has obvious therapeutic effect when compared with that of the single-use groups.
出处
《白求恩军医学院学报》
2010年第3期183-184,共2页
Journal of Bethune Military Medical College
关键词
吡格列酮
克罗米芬
胰岛素抵抗
排卵
Pioglitazone hydrochloride
Clomiphene citrae
Insulin resistance
Ovulate
