摘要
目的 探讨高原地区不同民族世居人群慢性胃炎胃黏膜组织内4种体液因子代谢水平的差异及其意义.方法 检测青海省相同海拔地区世居汉族与世居藏族人群慢性胃炎胃黏膜组织内脂质过氧化物丙二醛（MDA）、超氧化物歧化酶（SOD）、一氧化氮（NO）、黄嘌呤氧化酶（XOD）水平,并将两民族组间相关数据进行比较分析.结果 同海拔地区世居汉族居民胃黏膜组织内MDA含量和SOD活力[（2.2699±1.58908）nmol/mgprot、（134.6313＋48.35329）U/mgport]显著高于世居藏族居民[（1.7095±1.19474）nmol/mgprot、（109.5056±28.26794）U/mgport]（P〈0.05）,提示氧自由基与抗氧自由基代谢存在民族差别;而NO与XOD含量两民族间差异无统计学意义,提示NO与XOD代谢无民族差别.结论 高原地区慢性胃炎胃组织内MDA与SOD代谢水平在世居汉族和世居藏族人群间存在差别,推测世居汉族与世居藏族居民慢性胃炎发病率不同的原因可能是基于不同民族对高原缺氧的耐受能力不同所致.
Objective To compare the levels of four factors between gastric mucosa of Han and Tibetan patients with chronic gastritis residing in districts at the same altitude in Qinghai Province.Methods Levels of malonic aldehyde （ MDA） , superoxide dismutase （SOD） , nitric oxide （ NO） and xanthine oxidase （XOD） in gastric mucosa of Han and Tibetan patients with chronic gastritis resident in same altitude districts were examined, and a comparative study was performed.Results Levels of MDA and SOD were significantly higher in gastric mucosa of Han patients （2 2699 ± 1.58906 nmol/mgprot and 134.6313 ±48.35329 U/mgport, respectively） than those of the Tibetan （1.7095 ± 1.19474 nmol/mgprot and 109.5056 ± 28.26794 U/mgport, respectively） （P 〈0.05） , which indicated there were differences in metabolism of oxygen free radicals and antioxi-dant free radicals between 2 ethnics.However, there were no differences in NO and XOD levels between two ethnical groups, which suggested no ethnical difference in metabolism of the two factors.Conclusion There is ethnical difference in MDA and SOD metabolism in gastric mucosa of Han and Tibetan patients with chronic gastritis from same altitude district, which is presumably due to the different tolerance to the hypoxia at high altitude.
出处
《中华消化内镜杂志》
北大核心
2010年第6期307-308,共2页
Chinese Journal of Digestive Endoscopy
关键词
胃黏膜
缺氧
高海拔
少数民族
Corresponding author：YANG Gui-ying,Email： ygy618581@sina.com
