摘要
目的观察分子吸附再循环系统(MARS)人工肝在慢性重型肝炎治疗中临床生化指标的变化,探讨其疗效及安全性。方法对常规治疗效果欠佳的15例慢性重型乙型肝炎患者,在原有的治疗基础上加用MARS人工肝治疗,测定治疗前及治疗后血清生化指标的变化。结果加用MARS人工肝治疗之后,患者血清总胆红素、尿素氮、肌酐较治疗前明显下降,但血清转氨酶、白蛋白、胆固醇、凝血酶原时间、凝血酶原活动度及血清电解质、外周血细胞成分无显著变化。结论慢性重型肝炎常规治疗加用MARS可以显著降低以血清胆红素为代表的蛋白结合毒素及水溶性毒素,近期疗效及安全性较好。
Objective It is to observe the changes of serum biochemical markers in patients with chronic severe hepatitis after treatment with molecular absorbent recycling system（MARS） Artificial Liver and approach the curative effect and safety.Methods 15 patients of chronic severe hepatitis B who were below the mark after conventional treatment were treated with MARS.The changes of serum biochemical indexes were detected before and after treatment.Results After the treatment of MARS Artificial Liver,the serum total bilirubin,BUN and urea nitrogen were all obviously lower than those before treatment,but the difference on the transaminase,albumin,cholesterol,prothrombin time,prothrombin activity,serum electrolyte and components of cells in peripheral blood between the two groups were no significant.Conclusion Conventional treatment combined with MARS on chronic severe hepatitis can significant lower protein binding toxin and water-solubility toxin in which serum bilirubin is representative,and the curative effect in the near future and the safety is better.
出处
《现代中西医结合杂志》
CAS
2010年第20期2484-2485,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
分子吸附再循环系统
人工肝
慢性乙型重型肝炎
molecular absorbent recycling system
Artificial Liver
chronic severe hepatitis B
