摘要
目的研究血管紧张素转换酶（ＡＣＥ）基因多态性与非胰岛素依赖型糖尿病并发冠心病的关系。方法应用ＰＣＲ方法分析１４９例患者及１００例正常对照的ＡＣＥ基因型。结果①ＡＣＥ基因型及等位基因构成比，正常对照组与患者组差异无统计学意义；②ＤＤ型及Ｄ等位基因频率并发冠心病组显著高于无冠心病组（Ｐ＜０．０１）。
Objective:To clarify if ACE gene polymorphism attributes to the development of coronary heart disease in non insulin dependent diabetic mellitus(NIDDM).Methods:Angiotensin converting enzymegene(ACE) genotypes were dctected with PCR method in 149 patients with NIDDM and 100 normal controls who were all ethnically Han people from Hebei province.Results:①No significant differences were found in the genotype distribution between 149 NIDDM and 100 normal controls.②The DD genotype frequency was significantly higher in coronary heart disease (CHD) group (37%) than that in NIDDM without CHD (7%)( P < 0.01 ).Conclusion:ACE gene polymorphism attributes to development of coronary heart disease in NIDDM in ethnic Han people in Hebei province.
出处
《河北医科大学学报》
CAS
1999年第1期21-23,共3页
Journal of Hebei Medical University
基金
河北省科委资助
关键词
糖尿病
NIDDM
并发症
冠心病
ACE
rininase Ⅱ/anal
diabetes mellitus
non insulin dependent/compl
coronary disease/compl
