摘要
目的:探讨有早产征象孕妇尿液基质金属蛋白酶-9(MMP-9)水平,预测早产的价值。方法:用双抗体夹心ELISA法,检测无早产风险和征象的妊娠32周妇女(A组),先兆早产或早产胎膜早破妇女,追踪其中72h内未分娩者(B组),72h内分娩者(C组)及足月临产者(D组)尿液MMP-9水平。结果:A,B,C,D组孕妇尿液MMP-9浓度分别为2.82±0.51,6.17±0.97,7.10±0.72,7.41±0.86ng/ml,A组显著低于其他各组,差异有显著的统计学意义(P<0.01),B组与C组间差异也有显著的统计学意义(P<0.01)。尿液MMP-9水平预测未来72h内分娩的ROC曲线下面积为0.89。结论:尿液MMP-9水平在临产、破膜后明显增高,用于预测早产结局有一定的价值。
Objective：To explore the value of urinary matrix-metalloproteinase-9（MMP-9） concentration in predicting labor by examining the urine of pregnant women with the sign of premature delivery.Method：The MMP-9 concentration was tested by using the ELISA technique in the target groups：pregnancy of 32 weeks without sign of premature delivery and other risks（Group A）;pregnancy with threatened premature delivery or preterm premature rupture of the membrane（PPROM） who undelivered in 72 hours（group B）,and who delivered in 72 hours（group C）,labored in term pregnancy（group D）.Result：The concentration of MMP-9 in each group was 2.82±0.51ng/ml,6.17±0.97ng/ml,7.10±0.72ng/ml,7.41±0.86ng/ml,group A was significantly lower than that of each other groups（P0.01）,and there was a significant difference between group B and group C（P0.01）.The area under ROC curve of MMP-9 concentration was 0.89 that used as an index of the delivery status in 72 hours.Conclusion：The urinary matrix-metalloproteinase-9（MMP-9） concentration rises obviously in the procedures of labor and rupture of membrane,which is worth to be further developed in premature delivery.
出处
《现代妇产科进展》
CSCD
北大核心
2010年第5期336-338,共3页
Progress in Obstetrics and Gynecology
关键词
妊娠
分娩
早产
尿
基质金属蛋白酶
Pregnancy
Labor
premature
Urine
Matrix metalloproteinases
