摘要
目的：观察五加皮、茯苓、猪苓和山慈菇的遗传毒性。方法：应用活体小鼠骨髓嗜多染红细胞核试验（ＭＮＴ）和小鼠精子畸形试验。结果：五加皮各剂量所致的微核率和精子畸形率均低于正常对照组，分别为Ｐ＞００５，Ｐ＜００１。茯苓和猪苓各剂量所致的微核率和精子畸形率与正常对照组比较，无明显差异（Ｐ＞００５）。山慈菇诱发的微核率明显高于正常对照组（Ｐ＜００１）。结论：五加皮、茯苓和猪苓对体细胞及生殖细胞均无诱变损伤作用。
Objective:To study the genetictoxicity of Cortex Acanthophopanasia Radicis (CAR),Poria cocos (PC),Polyporus umbellatus (pers.) Fr PU(pers.)Fr and Bulbus Iphigeniae (BI).Methods:Abnormal sperm test of mouse and the micronucleus test of mouse bone marrow cell (MNT) were used.Results:The micronucleus rate in mouse bone marrow and the rate of abnormal sperm induced by CAR were significantly lower than those in NS group ( P <0 01).The differences were not significant in comparison of PC and PU(pers.)Fr groups with NS group ( P >0 05),but BI can increase sperm aberration and MN frequencies ( P <0 01).Conclusion:CAR,PC and PU(pers.) Fr did not bring about any genetic damage on germ cell and somatic cell.BI is mutagenic.
出处
《白求恩医科大学学报》
CSCD
1999年第1期8-10,共3页
Journal of Norman Bethune University of Medical Science
基金
国家自然科学基金
关键词
抗癌药
中药
五加皮
茯令
猪苓
山慈菇
致突变性
sperm aberration test
micronucleus test
mutagenicity
Cortex Acanthophopanasia Radicis
Poria cocos
Polyporus Umbellatus (pers.) Fr
Bulbus Iphigeniae
