摘要
目的:探讨肺黏膜相关淋巴组织型边缘区B细胞淋巴瘤(MALT-MZL)的临床表现、影像和病理学特点、治疗方法及其与淋巴上皮病(LEL)的关系。方法:报道1例肺MALT淋巴瘤并腮腺淋巴上皮病,对其进行病理组织学观察和免疫组织化检测,并回顾文献。结果:肺MALT淋巴瘤无明显临床表现,影像学特点为边界不清斑片影、结节影、团块影和叶段实变影,可见支气管充气征,缺乏特异性。病理示小淋巴细胞弥漫浸润,支气管、细支气管和肺泡上皮的浸润(淋巴上皮病变)是特征性的,但不特异。免疫组化可显示肿瘤的单克隆性,CD20和CD79a阳性。腮腺LEL是MALT淋巴瘤前期病变,能恶变为MALT淋巴瘤。结论:肺MALT淋巴瘤是一种罕见肿瘤,临床无特异性,确诊靠病理组织学和免疫组化检查,治疗以手术和化疗为主。LEL能恶变为MALT淋巴瘤。
Objective： To research the clinical manifestations, imaging and pathological characteristics, treatment methods of pulmonary macosa -associated lymphoid tissue- type marginal zone B -cell lymphoma （MALT- MZL） and its relationship with lymphoepithelial lesion （LEL）. Methods： Report one case of pulmonary MALT lymphoma with parotid lymphoepithelial lesion. Results： Pulmonary MALT lymphoma, had no obvious clinical manifestations, imaging features as the ill -defined spot films, nodules, lumps and leaf segment consolidation shadow, and the shadow can be seen bronchial inflatable sign, lack of specificity. Pathology showed diffuse infiltration of small lymphocytes, bronchus, bronchioles and alveolar epithelial infiltration （lymphoepithelial lesion） is not specific. Immunohistochemistry showed the tumor was monoelonal, CD20 and CD79a positive. Surgery and chemotherapy were the main treatment. Parotid LEL was the precancerous lesion of MALT lymphoma and LEL can be relapse into MALT lymphoma. Conclu- sion：Pulmonary MALT lymphoma is a rare tumor, clinical specific, diagnose depends on histopathology and immuno- histochemistry,features are not surgery and chemotherapy are main treatments. LEL can be relapse into MALT lymphoma.
出处
《现代肿瘤医学》
CAS
2010年第6期1206-1209,共4页
Journal of Modern Oncology
