期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

反式脂肪酸对心血管系统的危害 被引量：1

原文传递
导出
摘要 反式脂肪酸（transfattyacids，TFA）是一类含有反式双键的非共轭不饱和脂肪酸。越来越多的证据表明TFA对心血管损伤主要由两个方面的效应所致，即脂质效应和非脂质效应。研究证实，膳食中总TFA的比例每增加2％，冠心病的危险增加23％，若将膳食中总TFA的比例从2．1％下调到0．1％，心血管事件发生率可下降22％。非脂质效应涉及的领域较广，如内皮功能损伤、致炎、导致细胞凋亡、激活血小板、促进血栓形成、脂肪代谢分布异常、胰岛素抵抗等，因此成为近年来研究的重点。
作者 彭强 苏海
机构地区 南昌大学第二附属医院心内科
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2010年第5期475-477,共3页 Chinese Journal of Cardiology
关键词 反式脂肪酸 心血管系统 危害 不饱和脂肪酸 内皮功能损伤 心血管损伤 心血管事件 胰岛素抵抗
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献30

  • 1Mozaffarian D,Katan MB,Ascherio A,et al.Trans fatty acids and cardiovascular disease.N Engl J Med,2006,354:1601-1613.
  • 2苏海,俞建华.反式脂肪酸与心血管疾病[J].中华心血管病杂志,2007,35(6):586-588. 被引量：8
  • 3Mozaffarian D,Aro A,Willett WC.Health effects of trans-fatty acids:experimental and observational evidence.Eur J Clin Nutr,2009,63 Suppl2:S5-S21.
  • 4Ascherio A.Trans fatty acids and blood lipids.Atheroscler Suppl,2006,7:25-27.
  • 5Booker CS,Mann JI.Trans fatty acids and cardiovascular health:translation of the evidence base.Nutr Metab Cardiovasc Dis,2008,18:448-456.
  • 6Woodside JV,McKinley MC,Young IS.Saturated and trans fatty acids and coronary heart disease.Curr Atheroscler Rep,2008,10:460-466.
  • 7Dalainas I,Ioannou HP.The role of trans fatty acids in atherosclerosis,cardiovascular disease and infant development.Int Angiol,2008,27:146-156.
  • 8Mozaffarian D.Trans fatty acids-Effects on systemic inflammation and endothelial function.Atheroscler Suppl,2006,7:29-32.
  • 9Mozaffarian D,Pischon T,Hankinson SE,et al.Dietary intake of trans fatty acids and systemic inflammation in women.Am J Clin Nutr,2004,79:606-612.
  • 10Baer DJ,Judd JT,Clevidence BA.et al.Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets:a randomized crossover study.Am J Clin Nutr,2004,79:969-973.

二级参考文献16

  • 1Mozaffarian D, Katan MB, Ascherio A, et al. Trans fatty acids and cardiovascular disease. N Engl J Med, 2006,354 ( 15 ) : 1601 - 1613.
  • 2Kummerow FA, Zhou Q, Mahfouz MM, et al. Trans fatty acids in hydrogenated fat inhibited the synthesis of the polyunsaturated fatty acids in the phospholipid of arterial cells. Life Sci ,2004,74 (22) : 2707 -2723.
  • 3Giugliano D, Ceriello A, Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol,2006,48 (4) : 677-685.
  • 4Lemaitre RN, King IB, Raghunathan TE, et al. Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation, 2002, 105(6) :697-701.
  • 5Chatgilialoglu C, Ferreri C, Lykakis IN, et al. Trans-fatty acids and radical stress: what are the real culprits? Bioorg Med Chem, 2006,14( 18 ) :6144-6148.
  • 6Stender S, Dyerberg J. Influence of trans fatty acids on health. Ann Nutr Metab ,2004,48 (2) :61-66.
  • 7Ibrahim A, Natrajan S, Ghafoorunissa R. Dietary trans-fatty acids alter adipocyte plasma membrane fatty acid composition and insulin sensitivity in rats. Metabolism, 2005,54(2) :240-246.
  • 8Costa AG, Bressan J, Sabarense CM. Trans fatty acids: foods and effects on health. Arch Latinoam Nutr,2006,56( 1 ) :12-21.
  • 9Mozaffarian D, Pischon T, Hankinson SE, et al. Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr,2004,79(4) :606-612.
  • 10Baer DJ, Judd JT, Clevidence BA, et al. Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am J Clin Nutr, 2004,79 (6) :969-973.

共引文献7

同被引文献7

  • 1陶顺兴,周英田,王明.高温烹炸对食用油脂肪酸组成的影响[J].营养学报,1996,18(2):241-242. 被引量：13
  • 2Cerian R, Costa AM,Meirelles A JA. Optim Ization of the Physical Refining of Sunflower Oil Concerning the Final Contents of trans-Fatty Acids[J]. Indu.trialamt Engiaeering Chen:istry Research, 2008,47(3) : 681-692.
  • 3Wallace S K,Mozaffarian D. Trans-fatty Acid and Nonlipid Risk Fators[J]. Current Atho'osderis Reports,2009,11(6) :423-433.
  • 4Nishida C.Uauy R. WHO Scientific Update on Health Consequences of Trans Fatty Acids:Introduction[J]. European Journal o) Clh:ical Nutrition, 2009,63 (Su ppl 2) : S1- 4.
  • 5中华人民共和国国家标准.食用植物油卫生标准.GB2716-2005.北京:人民卫生出版社,2005.2-3.
  • 6Kummerow FA. Improving Hydrogenated Fat for the World Population[J]. Prevention and Control, 2005,1 (1) : 157-164.
  • 7郭丽莉,李昌模,若文靓,郑广奇.高温条件下食用油脂脂肪酸的变化[J].中国油脂,2011,36(10):16-19. 被引量：24

引证文献1

中华心血管病杂志
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部