摘要
目的探讨伴有阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea-hypopnea syndrome，OSAHS）的缺血性脑血管病患者（ischemic cerebrovascular disease，ICVD）血同型半胱氨酸（homocysteine，Hcy）水平。方法从南京脑卒中注册系统中筛选76例ICVD患者，行多导睡眠图（PSG）监测，并检测纤维蛋白原（FBG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、甘油三酯（TG）、血浆Hcy。结果76例患者中有57例存在呼吸暂停现象，其中53例（69．7％）诊断为OSAHS；排除4例中枢性呼吸暂停患者，将72例ICVD患者根据呼吸暂停加低通气指数（AHI）值分为4组：无呼吸暂停组19例，AHI值2．38±0．96，Hcy值（8．78±2．01）μmol／L；轻度OSAHS21例，AHI值14．14±4．37，Hcy值（12．91±3．00）μmol／L；中度OSAHS 24例，AHI值29．62±5．81，Hcy值（14．85±4．15）μmoL／L；重度OSAHS8例，AHI值46．75±2．82，Hcy值（19．30±4．82）μmol/L。4组间Hcy值差异有统计学意义（F=40．32，P〈0．01）。Hcy与AHI存在显著相关性（r=0．598，P〈0．01）。结论红ICVD患者中，OSAHS患病率较高，且以轻中度为主；Hcy在ICVD合并OSAHS患者时具有升高趋势，且随着阻塞程度的进展而加重。
Objective To investigate the relationship between obstructive sleep apnea-hypopnea syndrome （OSAHS） and plasma homocysteine （Hcy） levels in patients with ischemie cerehrovascular disease （ICVD）. Methods Seventy-six patients with ICVD were monitored with polysomnography （PSG） for 7--8 hours during sleeping. The levels of fibrinogen （ FBG）, high density lipoprotein cholesterol （ HDL- C）, low-density lipoprotein cholesterol （LDL-C）, triglyceride （TG） and plasma Hey were assessed. Results Of the 76 ICVD patients, 57 showed apnea symptom during sleeping, of which 53 （69. 7% ） were diagnosed with OSAHS and 4 with central sleep apnea. According to the mean apnea-hypopnea index （AHI） , the severity of apnea was classified as no apnea symptom （19 cases with mean AHI of 2. 38±0. 96 and Hcy level of （8. 78±2. 01 ）μmol/L）, mild apnea （21 cases with mean AHI of 14. 14 ±4.37 and Hcy level of （12. 91±3.00） μmoL/L）, moderate apnea （24 eases with mean AHI of 29. 62±5.81 and Hey level of （ 14. 85±4. 15） μmol/L） and severe apnea （8 cases with mean AHI of 46. 75±2. 82 and Hey level of （19.30±4. 82）μmol/L）. The level of Hey was statistical significant among these 4 groups （F = 40.32,P〈0.01） and correlated with the mean AHI（r =0.598,P〈0.01）. Conclusion Patients with ICVD have a high morbidity of OSAHS, mainly suffering from mild to moderate apnea ; The plasma Hcy level elevates in the ICVD patients with OSAHS and is correlated with the severity of apnea.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第6期408-411,共4页
Chinese Journal of Neurology
基金
南京市科技计划项目资助项习（200702066）
