摘要
以亨氏马尾藻为原料,运用超声波浸提工艺提取得到的岩藻聚糖硫酸酯(SPF),采用乙醇分级沉淀法纯化后经脱脂、脱蛋白得到初级纯化的岩藻聚糖硫酸酯,喂食高血脂症的小鼠,探讨其降血脂的功能。结果表明:亨氏马尾藻岩藻聚糖硫酸酯高、中、低3个剂量组的降血脂效果都优于药品对照脂必妥的降血脂效果,并且以高剂量的降血脂效果最佳,能够极显著(P<0.01)的降低总胆固醇、低密度脂蛋白、甘油三酯的含量,能显著(P<0.05)提高高密度脂蛋白的含量,且高于空白组;能显著降低动脉硬化指数,动脉粥样硬化指数AI1和AI2都有极显著影响(P<0.01)。说明亨氏马尾藻初级岩藻聚糖硫酸酯多糖具有明显的降血脂功能。
The Sulfated fucan （SPF） was extracted by ultrasonic extraction process from the Sargassum henslowianum, purified by ethanol, and then defatted, deproteinized to the primary fucoidan. The hyperlipidemia mice fed with purified primary fucoidan showed that： the hypolipidemia effect of the high, medium and low dose of fucoidan were all superior to the zhinbiticose. And the high dose was the best. The total cholesterol, low - density lipoprotein, triglyceride were all decreased significantly （ P 〈 0.01 ）, and high - density lipoprotein was increased significantly （P 〈0.05） than the control group. Arteriosclerosic index, AI1 and AI2 was decreased significantly（P 〈0.01 ）. The conclusion is that the Sulfated fucan from Sargassum henslowianum has obvious activity on lowing hyperlipidemia.
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2010年第5期28-31,共4页
Food and Fermentation Industries
基金
广东省科技厅资助项目(2007A020200006-15)
