摘要
目的观察五味子乙素(SchB)诱导的HSP27和HSP70对小鼠肝损伤的保护作用。方法采用扑热息痛(APAP)小鼠肝损伤模型,SchB和槲皮素给药后检测血清转氨酶水平,Western blot法检测小鼠肝脏HSP27和HSP70的表达。结果 SchB在APAP模型小鼠显著诱导HSP27和HSP70的表达及降低小鼠血清转氨酶水平,槲皮素可抑制上述作用。结论 SchB可通过诱导小鼠肝脏HSP27和HSP70的表达而发挥保肝作用。
Objective To investigate the protective effect of Schisandrin B（Sch B） on liver injury by inducing heat shock protein 27/70 in mice. Methods The mice treated with acetaminophen （APAP） were administered with Schisandrin B or quercetin,and then ALT and AST were determined and HSP27/70 was detected by Western blot. Results The Sch B inducing expression of hepatic HSP27/70 and decreasing ALT/AST were all reversed by quercetin. Conclusions Inducing hepatic HSP27/70 is one of the mechanism of Schisandrin B against liver injury.
出处
《齐齐哈尔医学院学报》
2010年第8期1177-1178,共2页
Journal of Qiqihar Medical University
基金
齐齐哈尔市科学技术计划指导项目
关键词
五味子乙素
肝损伤
热休克蛋白
槲皮素
Schisandrin B Liver injury Heat shock proteins （HSPs） Quercetin
