摘要
目的观察聚乙二醇干扰素(PEG-IFN)复合利巴韦林和苦参素治疗慢性丙型病毒性肝炎的临床疗效。方法将68例慢性丙型病毒性肝炎患者随机分为两组,I组:PEG-IFN180μg肌肉注射,1次/周;利巴韦林口服(0.3g,tid),并加用苦参素治疗。II组:PEG-IFN180μg肌肉注射,1次/周,利巴韦林口服(0.3g,tid)。两组疗程均为24周。定期检查肝功能,观察两组患者症状和体征的改善及不良反应的发生情况。结果 I组患者在ALT复常率、症状和体征改善及不良反应等方面均优于II组患者,两组比较差异具有统计学意义(P<0.05)。结论 IFN复合利巴韦林和苦参素治疗能有效改善肝功能、减少不良反应的发生,是目前治疗慢性丙肝较好的方法之一。
Objective To observe the clinical effects of the PEG-IFN combining ribavirin and oxymatrine in treating patients of Chronic Hepatitis C.Methods 68 patients of Chronic Hepatitis C were randomly divided into two groups：Group I were given PEG-IFN combining ribavirin and oxymatrine,PEG-IFN 180μg by intramscular injection weekly,plus ribavirin（take orally,0.3g,tid） with oxymatrine;GroupⅡwere given PEG-IFN 180μg by intramscular injection,Weekly,and ribavirin（take orally,0.3g,tid）,the research was conduct with a 24-weeks course.The hepatic function was checked,the changes of clinical symptoms and physical signs,and the side effects were observed.Results In group I,ALT and clinical symptoms and physical signs were improved markedly,the side effects were lower,there were statistical significance between two groups after treatment（P0.05）.Conclusion The PEG-IFN combining ribavirin and oxymatrine therapy can markedly improve hepatic function,decrease side effects.It is one of the best therapy in chronic Hepatitis C.
出处
《当代医学》
2010年第16期141-142,共2页
Contemporary Medicine
