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螺内酯与卡托普利治疗老年人心力衰竭的疗效观察 被引量:2

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摘要 目的观察螺内酯与卡托普利治疗老年人慢性心力衰竭的疗效及安全性。方法 73例老年慢性心力衰竭患者随机分为卡托普利联合螺内酯组(A组)和卡托普利组(B组)。B组常规给予卡托普利、洋地黄制剂、速尿、倍他乐克治疗;A组在常规治疗基础上加用螺内酯20mg/d,连续用药6个月,对比治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、短轴缩短率(FS)及血生化各项指标的变化。结果两组治疗后超声心动图各项指标均得到改善,但A组LVEDD的缩小更明显[(59.4±7.9)mm比(46.7±3.5)mm,P0.01]。两组治疗前后血生化各项指标均无显著变化,不良反应发生率相仿(P>0.05)。结论小剂量螺内酯联合卡托普利能改善老年慢性心力衰竭的左心室重构,且安全性良好。
作者 张卡 张效民
机构地区 舞阳县中医院
出处 《当代医学》 2010年第16期133-134,共2页 Contemporary Medicine
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参考文献4

  • 1慢性收缩性心力衰竭治疗建议[J].中华心血管病杂志,2002,30(1):7-23. 被引量:2411
  • 2Zannad F,Alla F,Dousset B,et al.Limitation of excessive ectraceltular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure:insights from the randomized aldactone evaluation study (RALES).Rales Investigators[J]. Circulation,2000,102(22):2700-2706.
  • 3Bauersach J,Heck M,Fraccarollo D,et al.Addition of spironolactone to angietension converting enzyme in heart failure improve endothelial vasomotor dysturction.role of vascular superoxide anion formation and endothelial nitricoxide synthase expression[J].J Am Coil Cardiol,2002 59(2):351-558.
  • 4胡大一,吴彦.规范心力衰竭治疗 加强患者管理[J].中华心血管病杂志,2005,33(6):495-497. 被引量:124

二级参考文献11

  • 1Stewart S, Maclntyre K, Macleod MM, et al. Trends in hospitalization for heart failure in Scotland, 1990-1996. An epidemic that has reached its peak? Eur Heart J,2001, 22:209-217.
  • 2Remme WJ, Swedberg K. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J,2001,22:1527-1560.
  • 3Felker GM, Adams KF Jr, Konstam MA, et al. The problem of decompensated heart failure: nomenclature, classification, and risk stratification. Am Heart J,2003,145:S18-S25.
  • 4Berry C, Murdoch DR, McMurray JJ. Economics of chronic heart failure. Eur J Heart Fail,2001,3:283-291.
  • 5Coletta AP, Cleland JG, Freemantle N, et al. Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM. Eur J Heart Fail,2003,5:697-704.
  • 6Bardy GH, Lee KL, Mark DB, et al. Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators.Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med, 2005, 352:225-237.
  • 7Cleland JG, Daubert JC, Erdmann E, et al. Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med, 2005,352:1539-1549.
  • 8Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet,2004 ,364:141-148.
  • 9Arnold JM, Yusuf S, Young J, et al. HOPE Investigators. Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation,2003,107:1284-1290.
  • 10Fox KM. European trial on reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet,2003,362:782-788.

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