摘要
目的:研究维族胆囊胆固醇结石患者与汉族胆固醇结石患者、维族非结石患者肝组织SCP2的表达情况和血脂变化。方法:应用Western blot技术,测试维族胆囊胆固醇结石患者、汉族胆固醇结石患者和维族非结石患者各20例肝组织SCP2的蛋白表达水平差异,并采用生物化学技术检测其血脂改变。结果:维族与汉族胆囊胆固醇结石患者肝组织SCP2蛋白表达水平无显著性差异;维族胆囊胆固醇结石患者肝组织SCP2蛋白表达水平较维族非结石组高,有显著性差异;各组间血脂无显著性差异。结论:胆囊胆固醇结石患者肝组织SCP2蛋白水平升高,SCP2表达上调可能是胆囊胆固醇结石形成的重要原因;维族和汉族胆固醇结石患者的SCP2蛋白表达无显著性差异。
Objective：To investigate the expression level of liver SCP2 in Uygur and han Nationality patients with cholesterol gallstone and Uygur Nationality patients without gallstones and changes of serum lipid in Xinjiang levels.Methods：The expression level of liver SCP2 protein was studied in 20 Uygur Nationality patients and 20 han Nationality patients with cholesterol gallstone and 20 Uygur Nationality patients without gallstones by Western blot method;the serum lipid levels were also determined by biochemical techniques.Results：There were no significant differences between 20 Uygur Nationality patients and 20 han Nationality patients with cholesterol gallstone,however,the expression of SCP2 protein was increased significantly in cholesterol gallstone patients of Uygur Nationality as compared with non-gallstone patients of Uygur Nationality.There were no significant differences between the serum lipid levels of the three groups.Conclusion：SCP2 gene was over expressed in cholesterol gallstone patients of Uygur Nationality in Xinjiang,indicating that SCP2 maybe one of the important etiologic causes of cholesterol gallstones.
出处
《现代临床医学》
2010年第3期178-179,共2页
Journal of Modern Clinical Medicine
