摘要
目的探讨阿托伐他汀治疗急性脑梗死合并高脂血症、颈动脉粥样硬化斑块患者的临床疗效。方法选择急性脑梗死合并高脂血症、颈动脉粥样硬化斑块患者62例,在神经科常规治疗基础上给予阿托伐他汀联合治疗,分别于入院时,治疗第8、12、24周动态监测患者的血脂水平,并进行颈动脉超声检查评估颈动脉粥样硬化斑块内膜-中层厚度。结果治疗前、后比较,患者各项血脂指标、颈动脉斑块内膜-中层厚度均有显著改善,差异有统计学意义(P<0.05);且神经功能缺损较治疗前显著改善,有效率为59.7%。结论阿托伐他汀除有良好的降血脂作用外,还有稳定甚至减轻动脉粥样硬化的作用。
Objective To evaluate the clinical effect of atorvastatin calcium for acute cerebral infarction with hyperlipidemia and carotid artery atherosclerosis.Methods Sixty-two patients with acute cerebral infarction complicated with hyperlipemia and atherosclerotic plaque were choosen,and therapeutic alliance of atorvastatin was given on the basis of conventional therapy,the level of blood fat was dynamically monitored in admission time,in 8,12,24 weeks after treatment,carotid ultrasound was performed to evaluate the thickness of inner membrance-intercellular layer of carotid atherosclerotic plaque.Results The blood lipids and the thickness of inner membrance-intercellular layer of carotid atherosclerotic plaque were significantly improved than those for pretherapy（P〈0.05）;neurologic impairment were obviously improved than that in prior treatment,the effective rate was 59.7%.Conclusion Atorvastatin has stabilized even ruduced atherosclerotic besides its anti-lipidic role.
出处
《医学综述》
2010年第11期1743-1745,共3页
Medical Recapitulate
