摘要
目的：分析闭塞性肺动脉高压患者的自然病程。方法：对130例闭塞性肺动脉高压患者以通讯或门诊方式进行随访，将生存结果与临床心电图，X线胸片，超声心动图，血液动力学资料进行相关分析。不能解释的肺动脉高压组（UPH组）与慢性栓塞性肺动脉高压组（CTEPH组）两组对照分析。结果：本组闭塞性肺动脉高压患者平均随访时间5．86±4．63年，其生存函数曲线显示2年、3年、5年生存率分别为79.0％，73.0％，50.0％。UPH组与CTEPH组生存率比较，后者较好。影响生存率的因素有心功能，肺动脉压力，心输出量，心脏指数，心胸比率，动脉血氧分压等。结论：闭塞性肺动脉高压的预后不乐观，尤以不能解释的肺动脉高压更严重。降低肺血管压力，改善心功能是提高闭塞性肺动脉高压生存率的重要环节。
Objective:To analyse the natural history in patients with oblitcrative pulmonary hypertension.Methods: The natural history in 130 patients were followed up through communication and clinic. The correlative analysis was made between the survival and clinical data, including Electrocardiogram(ECG),Ultracardiography (UCG ),Cardiac/Thoracic (C/T),blood gases and hemodynamic changes. The comparison of patients with unexplained pulmonary hypertension(UPH) group and chronic thremboembolic pulmonary hypertension (CTEPH) group were made.Results: The average course in 130 patients with obliterative pulmonary hypertension was 5. 86±4. 63 years. The survival curves showed that survival rate was 91. 3 % at two-year, 79. 7 % at three-year and 60.0% at five-year. The single correlation factors that influencing prognosis were pulmonary artery oxygen pressure(PaO,),C/T,cardiac output(CO),cardiacindex (CI) and pulmonary artery pressure (PAP). The univariate factors were PaO,,PAP,right ventricular extension diameter(RVED) and deep venous trouble(DVT). The survival rate of patients with CTEPH was better than those with UPH.Conclusion: Prognosis of obliterative pulmonary hypertension is poor. Espicially the prognosis of unexplained pulmonaryhypertension is more severe. The decrease in pulmonary arterial pressure and the amendment of cardiac function are important to improve patients prognosis.
出处
《中国循环杂志》
CSCD
北大核心
1999年第1期28-30,共3页
Chinese Circulation Journal
关键词
肺动脉高压
自然病程
诊断
治疗
病例分析
Obliterative pulmonary disease
Pulmonary hypertension
Natural history
