摘要
目的探讨雾化吸入沙丁胺醇合并奈多罗米治疗毛细支气管炎对血清IL-12及INF-γ的影响。方法2007年2月～2009年12月86例毛细支气管炎患儿随机分为常规疗法（常规组）及雾化吸入沙丁胺醇合并奈多罗米治疗组，治疗前、后分别测定炎性细胞因子IL-12及INF-γ，并与健康儿童比较。结果患儿入院当天血清中IL-12及INF-γ水平较健康组低，差异有统计学意义（P〈0．05）；治‘疗组治疗后IL-12及INF-γ水平逐渐升高，与对照组比较差异有统计学意义（P〈0．05）。结论雾化吸入沙丁胺醇合并奈多罗米治疗毛细支气管炎能升高Thl细胞水平，调节TH1／TH2免疫应答平衡。
Objective To explore the effect of atomization salbutamol combined with nedocromil on serum interleukin - 12 and interfer- on - γ in pediatric bronchiolitis. Methods Eighty six children diagnosed with bronchiolitis are randomly divided into two groups ： conventional therapy group and thymosin group. The serum level of interleukin - 12 and interferon - γ were detected by enzyme linked immunosorbent assay before and after treatment. To observe their clinical effect and compare with normal children. Results The level of interleukin - 12 and interfer- on - γ, in bronchiolitis children before treatment were significantly lower than those in normal children （ P 〈 0. 05 ）. After treatment, the level of interleukin - 12 and interferon - γ in therapeutic group was higher than those in control group （P 〈 0. 05）. Conclusion Atomization salbutamol combined with nedocromil can enhance serum of type 1 cytokine, and regulate typel and type 2 cytokine balance.
出处
《中外医学研究》
2010年第11期11-13,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
