摘要
目的:观察枳苓化浊汤对慢性萎缩性胃炎患者中医临床症状及胃动素的影响。方法:选择该病门诊患者108例,随机分为两组。治疗组58例予枳苓化浊汤口服,对照组50例予多潘立酮片(吗丁啉)口服。2组均以3个月为1个疗程。结果:两组临床疗效比较,治疗组痊愈11例,显效31例,有效12例,无效4例,总有效率为93.10%(95%CI=82.85%～98.06%);对照组痊愈3例,显效21例,有效7例,无效19例,总有效率为62.00%(95%CI=48.55%～75.45%);两组综合疗效比较(u=3.2383,P=0.0017),差异显著;治疗后两组血浆胃动素含量均明显上升,治疗组与对照组比较,有显著性差异(P<0.001)。结论:枳苓化浊汤治疗萎缩性胃炎较多潘立酮片能明显改善患者胃脘胀满的临床症状,提高血清胃动素含量,增强胃动力,促进胃排空,其收益为OR=0.12(95%CI=0.04～0.39),NNT=3(95%CI=2.15～6.41)。
Objective ： To observe the effect of Zhi-ling Hua-zhuo Decoction on gastric emptying in the patients with chronic atrophic gastritis. Method： 108 cases in out-patient clinic were divided into two groups randomly. 58 cases in treatment group were treated by Zhi-ling Hua-zhuo Decoction, and 50 ones in control group done by domp- eridone. One treatment course included 3 months. Result： On symptoms, in treatment group 11 cases were recovered, 31 ones excellent, 12 ones effective and 4 ones ineffective. The total effective rate was 93.10% （95% CI = 82. 85% -98.06% ）. And in control group 3 cases were recovered, 21 ones excellent, 7 ones effective and 19 ones ineffective. The total effective rate was 62.00% （ 95% CI = 48.55% -75.45% ）. About comprehend curative effect, u = 3.238 3, P = 0. 001 7, the difference was significant. After treatment motilin in blood plasma was raised in the two groups markedly, but it was more obviously in treatment group than in control group, and the difference had statistical significance （P 〈 0. 001 ）. Conclusion： Zhi-ling Hua-zhuo Decoction can ameliorate the clinical symptoms of gastric inflated feeling in chronic atrophic gastritis, and does better than domperidone. It also can improve motilin in blood motilin, strengthen gastric motive power, promote gastric emptying, and OR = 0. 12 （95% CI =0. 04-0. 39） ,NNT =3 （95% CI =2. 15-6.41 ）.
出处
《山西中医》
2010年第6期14-15,共2页
Shanxi Journal of Traditional Chinese Medicine
