摘要
目的:评估纳洛酮治疗慢性Ⅱ型呼吸衰竭的疗效。方法:将46例慢性Ⅱ型呼吸衰竭患者随机分成两组,在常规治疗基础上纳洛酮组加用纳洛酮注射剂,首剂负荷量0.4～0.8 mg加入生理盐水20 mL中静脉推注,以后给予纳洛酮注射剂1.6 mg加入生理盐水250 mL中静脉滴注;对照组用可拉明1.875 g加入生理盐水250 mL缓慢静滴,每日1次,疗程均为5 d,观察临床症状、体征、肺功能、血气分析及不良反应。结果:治疗后观察组在临床症状、体征、肺功能、血气分析等各项观察指标的改善上明显优于对照组,差异具有统计学意义(P<0.05);纳洛酮组总有效率为91.30%,对照组为65.22%,差异具有统计学意义(P<0.05);且纳洛酮组未见明显不良反应。结论:纳洛酮治疗慢性Ⅱ型呼吸衰竭患者是一种安全有效的方法。
Objective：To estimate the eiinical effect of Naloxone in the treatnaent of chronic type Ⅱ respiratory failure. Methods：46 cases of chronic type Ⅱ respiratory failure were randomly divided into two groups,namely the Naloxone group and the controlled group.Mter 0.4-0.8 mg bolus injection in 20 mL NS,the routine treatment 1.6 mg of Naloxone in 250mL NS was used once per day in the Naloxone group.The course of treatment was 5 days.The clinical symptom, sign, lung function,blood gas analysis and side effect were observed. Results：There was significantly difference between two groups in lung function, blood gas analysis （P〈0.05）.The curative rate of Naloxone group was significantly higher than that of control group （91.30% vs 65.22%, P〈0.05）, and Naloxone had few side effects. Conclusion： Naloxone is safe and effective in treating chronic type Ⅱ respiratory failure, which is worth utilizing widely in clinic.
出处
《赣南医学院学报》
2010年第2期210-211,共2页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
纳洛酮
呼吸衰竭
Naloxone
Respiratory failure
