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尿微量白蛋白与冠状动脉病变程度的相关性分析 被引量:6

The Relationship between Microalbuminuria and Coronary Artery Disease
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摘要 目的:研究尿微量白蛋白与冠心病的相关性。方法:按冠状动脉造影诊断标准将116例患者分为冠心病组(82人)与非冠心病组(34人),测定晨尿白蛋白/肌酐浓度值(ACR),比较两组患者尿ACR并分析ACR与冠脉病变程度的相关性。结果:冠心病组ACR显著高于非冠心病组的;ACR与冠脉计分呈显著的直线正相关。结论:冠心病患者ACR水平升高,微量白蛋白尿与冠状动脉病变范围和程度密切相关,且对冠状动脉狭窄程度具有独立预测价值。 Objective:To investigate the relationship between microalbuminuria and coronary artery disease(CAD).Methods:According to the diagnostic standard of coronary artery angiography,116 patients were divided into CAD group (82 patients) and non-CAD group (34 patients).The albumin and creatinine concentrationratio ratio(ACR) in morning urine samples from patients of both groups was estimated and compared.The correlation of ACR to the extent of coronary lesions was analyzed.Results:ACR in the CAD group was significantly higher than that in non-CAD group.A distinctly linear positive correlation existed between ACR and the score of the coronary lesions.Conclusion:ACR increase in patients with CHD.Micoalbuminuria was associated with the severity of coronary lesions in patients with CHD and is an independent predictor of CAD.
出处 《华西医学》 CAS 2009年第10期2609-2612,共4页 West China Medical Journal
关键词 尿微量白蛋白 冠状动脉疾病 相关性分析 albuminuria coronary disease correlation
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  • 1DECKERT T, FELDT-RASMUSSEN B, BORCH-JOHNSEN K. Album inuria reflects widesp read vascular damage[J]. Diabetologia, 1989, 32: 219.
  • 2MURTAUGH M A, JACOBS,D R JR. Correlates of urinary album in exertion in young adult blacks[J]. Ep idemid, 2003, 158: 676.
  • 3YUYUN M, KHAW K, LUBEN R, et al. A prospective study of microalbuminuria and incident coronary heart disease and its prognostic significance in a Bitish population. The EPIC-Norfolk Study [J]. Am J Epidemiol, 2004,159:284-293.
  • 4刘力生,龚兰生.中国高血压防治指南[M].北京:人民卫生出版社,2005.33.
  • 5周翔海,纪立农.尿白蛋白肌酐比与UAER相关性分析[J].辽宁实用糖尿病杂志,2001,9(3):23-25. 被引量:11
  • 6王玉国,徐宏亮,古晓杰.尿微量白蛋白检测及临床应用[J].中华医学检验杂志,1998,21(1):46-46. 被引量:23
  • 7HANS L,VACLAV FIDLER,GILLES FH, et al. Uirnary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population[J]. Circulation, 2002,106 : 1777.
  • 8YUDKINJS, FORRESTRD, JACKSON CA. Microalbuminuria as predictor of vascular disease innon-diabetie subjects: Islington diabetessurvey [J]. Lancet, 1988, 2:530-533.
  • 9BORCH-JOHNSEN K, FELDT-RASMUSSEN B, STRANDGAARD S , et al. Urinary albumin excretion an independent predictor of ischemic heart disease [J]. Arterioscler Vasc Biol,1999, 19:1992-1997.
  • 10MANN JF, GERSTEIN HC, POGUE J, et al. Renal insufficiency as a of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial [J]. Ann Intern Med, 2001, 134: 629-636.

二级参考文献18

  • 1李秀钧,邬云红.糖尿病是一种炎症性疾病?[J].中华内分泌代谢杂志,2003,19(4):251-253. 被引量:253
  • 2[1]Mattock MB, Keen H, Viberti GC, et al. Coronary heart disease and urinary albumin excretion rate in type 2(non-insulin dependent)diabetic patients. Diabetologia 1988 ;31:82.
  • 3[2]Deckert T, Yokoyama H, Mathiesen E, et al. Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes. BMJ 1996; 312: 871.
  • 4[3]Damsgaard EM, Froland A, Jorgensen OD. Microalbuminuria as predictor of increased mortality in elderly people. BMJ 1990; 300: 297.
  • 5[4]American Diabetes Associaton: Consensus development conference on the diagnosis and management of nephropathy in patients with diabetes mellitus ( Consensus Statement). Diabetes Care 1994; 17:1357.
  • 6[5]Cundy TF, Nixon D, Berkahn L, et al. Measuring the albumin excretion rate: agreement between methods and biological variability. Diabet Med 1992;9:138.
  • 7[6]Mogensen CE, Keane WF, Bennett PH, et al. Prevention of diabetic renal disease with spectial reference to microalbuminuria. Lancet 1995;346:1080.
  • 8[7]Ng WY, Lui KF, Thai AC. Evaluation of a rapid screening testfor microalbuminuria with a spot measurement of urine albumin- creatinine ratio. Ann Acad Med Singapore 2000;29:62.
  • 9Pradhan AD,Manson JE,Rifai N,et al.C-reactive protein,inter-leukin6,and risk of developing type 2 diabetes mellitus[J].JAMA,2001,286(3):327-334.
  • 10Pickup JC,Mattock MB,Chusney GD,et al.NIDDM as disease of the in-nate immune system:association of acute-phase reaction and inter-leukin-6 with metabolic syndrome X[J].Diabetologia,1997,40 (11):1286-1292.

共引文献88

同被引文献41

  • 1王贵荣,段永桂,周钧.冠心病患者血中C反应蛋白、纤维蛋白原和白细胞变化及其意义[J].天津医药,2004,32(8):515-516. 被引量:7
  • 2Schroecksnadel K, Grammer TB, Boehm BO, et al. 'lotal homocys-teine In patients with angiographic coronary artery disease correlates with in- flammation markers [ J ]. Thromb Haemost ,2010,103 ( 5 ) :926-935.
  • 3Mujibul Haq AM, Giasuddin AS, Huque MM. Serum total homocys- teine and lipoprotein(a) levels in acute myocardial infarction and their response to treatment with vitamins [ J ]. J coil Physicians Surg Pak,2011,21 (5) :266-270.
  • 4王燕,李勇.尿微量白蛋白与冠状动脉病变的关系[J].中华内科杂志,2007,46(12):981-983. 被引量:6
  • 5LiY,WangJG,DolanE,etal.Ambulatoryarterialstiffnessindexderivedfrom24-hourambulatorybloodpressuremonitoring[J].Hypertension,2006,47(3):359-364.
  • 6LiuZ,hesseC,CurryB,etal.Ambulatoryarterialstiffnessindexisnotcorrelatedwiththepressorresponstostressorsinnoemotensivehumens[J].JHypertens,2009,27(4):763-768.
  • 7GensiniGG.Amoremeaningfulscoringsystemfordeterminingtheseverityofcoronaryheartdisease[J].AmJCardiol,1983,51(3):606.
  • 8HansenTW,LiY,StaessenJA,etal.Independentprognosticvalueoftheambulatoryarterialstiffnessindexandaorticpulsewavevelocityinageneralpopulation[J].JHumHypertens,2008,22(3):214-216.
  • 9PerkovicV,VerdonC,NinomiyaT,etal.Therelationshipbetweenproteinuriaandcoronaryrisk:asystematicreviewandmeta-analysis[J].PLosMed,2008,5(10):e207.
  • 10Sharma S, Halaut VS, Dixit R, et al. Microalbuminuria and C- reactive protein as a predictor of coronary artery disease in patients of acute chest pain[J]. J Cardiovasc Dis Res, 2013, 4 (1):37-39.

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