sCD44分子与原发性开角型青光眼被引量：1

导出

摘要随着对可溶性黏附分子CD44（sCD44）生物学功能和化学本质的深入认识,人们发现sCD44分子参与了原发性开角型青光眼（primary open-angle glaucoma,POAG）的病理过程,它可以引起小梁网细胞结构和功能异常、细胞凋亡,其对视网膜神经节细胞具有毒性作用.文中就sCD44分子与POAG关系的研究进展作一综述.

作者陈燕萍吴瑜瑜

机构地区福建医科大学附属第二医院眼科

出处《中国实用眼科杂志》 CSCD 北大核心 2010年第5期429-431,共3页 Chinese Journal of Practical Ophthalmology

基金泉州市优秀人才培养专项经费资助项目（08A15）

关键词青光眼开角型小梁网 scD44分子

分类号 R775.2 [医药卫生—眼科]

引文网络
相关文献

参考文献24

1Knepper PA,Coossens W,Hvizd M,et al.Glycosaminoglycans of the human trabecular meshwork in primary open-angle glaucoma[J].Invest Ophthalmoi Vis Sci,1996,37:1360-1367.
2Knepper PA,Miller AM,Choi J,et al.Hypophosphorylation of Aque-ousHumor sCD44 and Primary Open-Angle Glaucoma[J].IOVS,2005,46:2829-2837.
3Cichy J,Bals R,Potempa J,et al.Proteinase-mediated release of epithelial cell-associated CD44.Extracellular CD44 complexes with components of cellular matrices[J].J Biol Chem,2002,277 (46):.
4Knepper PA,Miller AM,Choi J.et al.Is POAC an adaptive senescence phenomenon?[J].Invest Ophthalmoi Vis Sci,2003,44:E-Abstract 4406.
5Miller AM,Choi J,Knepper PA.Does the vitreous humor act as a reservoir for eytotoxic sCD44?[J].Invest ophthalmoi Vis Sci,2002,43:1033.
6Choi AM,Miller J,Yue J.Soluble CD44 Is Cytotoxic to Trabecular Meshwork and Retinal Ganglion Cells In Vitro[J].Invest Ophthalmoi Vis Sci,2005,46:214-222.
7Schwartz DM,Jumper MD,Lui GM,et al.Corneal endothelial hyaluronidase:a role inanterior chamber hyaluronic acid catabolism[J].Cornea,1997,16(2):188-191.
8Knepper PA.GoossensW.Mayanil CS.CD44H localization in primary open-angle glaucoma[J].Invest Ophthalmoi Vis SCi,1998,39:673-680.
9Knepper PA,Mayanil CS.Goossens W,et al.Aqueous humor in primary open-angle glaucoma contains an increased level of CD44s[J].Invest Ophthalmoi Vis Sci,2002,43(1):133-139.
10Nolan,MJ,Yue JT,Samples JR,et al.Oxidative Stress Induces Secretion of Hypophosphorylated Soluble CD44 by Trabecular Meshwork Cells in Culture[J].Invest Ophthalmoi Vis Sci,2006,47:E-Abstract 1840.

二级参考文献58

1吴瑜瑜,陈书扬,朱益华,李贵州,蔡俊锋.人眼小梁网细胞的体外培养[J].福建医科大学学报,2005,39(1):24-26. 被引量：6
2Rosenbaum DM, Rosenbaum PS, Singh M, Gupta G, Gupta H,Li B, et al. Functional and morphologic of two methods to produce transient retinal ischemia in the rat [J]. J Neuroophthalmol 2001;21(1) :62-68.
3Tezel G, Wax MB. Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells[J]. JNeurosci 2000;20(23):8693-8700.
4Klocker N,Kermer P, Weishaupt JH, Labes M,Ankerhold R,Bahr M. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo doses not exclusively depend on phosphatidy inosltol3'-kinase/protein kinase B signaling[J
5Wen R, Cheng T, Li Y, Gao W, Steinberg RH. Alpha-2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage[J]. J Neurosci 1996; 16 ( 19 ): 5986-5992.
6Levkovitch-Verbin H, Quigley HA, Kerrigan-Baumrind LA,D'Anna SA, Kerrigan D, Pesse ME. Optic nerve transaction in monkeys may result in secondary degeneration of retinal ganglion cells[J]. Invest Ophthalmol Vis Sci 2001 ;42(5) :975-982.
7Daugeliene L, Niwa M, Hara A, Matsuno H, Yamamoto T, Kitszawa Y, et al. Transient ischemic injury in the rat retina caused by thrombotic occlusion-thrombolytic reperfusion [J]. Invest Ophthalmol Vis Sci 2000;41(9):2743-2747.
8Hare W,WoldeMussie E, Lai R,Ton H,Ruiz G,Feldmann B,et al. Efficacy and safety of memantine,an NMDA-type openchannel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey [J]. Surv Ophthalmol 2001 ;45(Suppl 3): S
9Levkovitch-Verbin H, Quigley HA, Martin KR, Valenta D,Baumrind LA, Pease ME. Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats [J]. Invest Ophthalmol Vis Sci 2002;43(2) :402-410.
10Donello JE, Padillo EU, Webster ML, Wheeler LA, Gil DW.Alpha (2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia[J]. J Pharmcol Exp Ther 2000;296(1): 216-223.