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老年2型糖尿病患者骨质疏松与冠状动脉钙化的关系 被引量：3

Association of osteoporosis and coronary artery calcification in elderly patients with type 2 diabetes mellitus
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摘要 目的探讨2型糖尿病患者骨质疏松与冠状动脉钙化的关系。方法根据双能X线骨密度检查结果，将82例老年2型糖尿病患者分成骨质疏松组与非骨质疏松组，分别进行冠状动脉双源CT检查，计算冠状动脉总钙化积分（TCS），同时测定血钙（Ca）、磷（P）、甲状旁腺素（PTH）水平等。结果骨质疏松组与非骨质疏松组比较，血钙[（2．32±0．15）mmol／L对（2．04±0．20）mmol／L]、PTH[（5．64±1．97）pmol／L对（5．01±1．93）pmol／L]、TCS[（374．4±433．5）分对（242．5±224．8）分]，差异均有统计学意义（t值分别为5．790、5．331、2．248，P〈0．05）。相关性分析显示，2型糖尿病患者TCS与L2、L3、L4、股骨颈骨密度呈负相关（r值分别为-0．310、-0．246、-0．290、-0．284，P〈0．05），与钙、PTH呈正相关（r值分别为0．324、0．575，P〈0．05）。结论2型糖尿病患者骨质疏松与冠状动脉钙化之间存在一定的相关性，钙磷代谢异常及代偿性PTH水平升高可能起到一定的作用。 Objective To investigate the association of osteoporosis and coronary artery calcification in elderly patients with type 2 diabetes mellitus （T2DM）. Methods A total of 82 elderly T2DM patients underwent dual-energy x-ray absorptiometry scanning （DXA） of lumbar spine and femur neck for getting bone mineral density （BMD）, and dual-source computed tomography （DSCT） of coronary artery for calculating calcification score and total calcification score （TCS）. All subjects were divided into two groups： osteoporosis group and non-osteoporosis group. The levels of serum calcium （Ca）, parathyrin （PTH）, phosphorus （P）, alkaline phosphatase （AKP）, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein-cholesterol （HDL-C）, low density lipoprotein- cholesterol （LDL-C） and glycosylated hemoglobin （HbAlc） were detected. Results Compared with non-osteoporosis group, the levels of serum Ca, PTH and TCS were higher [（2.32 ±0.15） mmol/L vs. （2.04±0.20） mmol/L; （5.64± 1.97） pmol/L vs. （5.01± 1.93） pmol/L; （374.4± 433.5） scores vs. （242.5±224.8） scores, t=5.790, 5. 331 and 2. 248, all P〈0.05; inosteoporosis group. Correlation analysis showed TCS was negatively associated with BMD of L2 4 and femur neck, while was positively associated with serum Ca and PTH （r=0. 310, 0. 246, 0. 290, 0. 284 and 0. 324, 0. 575 all P〈0.05）. Conclusions Osteoporosis is associated with coronary atherosclerosis. TCS could be considered as an index for judging the relationship between osteoporosis and coronary atherosclerosis.
作者 袁放 吴天凤 郑和昕 冯越 谢海宝
机构地区 杭州市浙江医院内分泌科 杭州市浙江医院放射科 杭州市浙江医院老年病研究所
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2010年第5期367-369,共3页 Chinese Journal of Geriatrics
关键词 骨密度 冠状动脉硬化 糖尿病 2型 Bone density Coronary arteriosclerosis Diabetes mellitus,type 2
分类号 R580 [医药卫生—内分泌] R587.1 [医药卫生—内分泌]
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  • 1陶国枢,张京立.骨质疏松症与心血管疾病[J].中国骨质疏松杂志,1998,4(1):45-46. 被引量：5
  • 2张咏梅,林华.冠心病和骨质疏松[J].中国骨质疏松杂志,2005,11(2):266-268. 被引量：23
  • 3赵圆,刘文亚,邢艳,周晓辉,徐新娟,杨文.老年人骨质疏松与冠状动脉硬化关系的初步探讨[J].中国骨质疏松杂志,2006,12(3):250-252. 被引量：6
  • 4Bucay N, Sarosi I, Dunstan CR, et al. Osteoprotegerin deficient mice develop early onset osteoporosis and arterial calcification. Gene Develop, 1998,9 : 1260-1268.
  • 5Ohmori R, Momiyama Y, Taniguchi H, et al. Plasma osteopomin levels are associated with the presence and extent of coronary artery disease. Atheroseler, 2003, 170:333-337.
  • 6Imamura A, Okumura K, Ogawa Y, et al. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta, 2006, 371 :66-70.
  • 7Sutton tyrrell K, Alcom HG, Wolfson SK Jr, et al. Predictors of carotid stenosis in older adults with and without isolated systolic hypertension . Stroke, 1993,24 : 335-361.
  • 8Kruger MC, Horrobin DF. Calcium metabolism, osteoprosis and essential fatty acids: a review. Prog Lipid Res,1997,36:131-151.
  • 9Ramsey Goldman R, Manzi S. Association of osteoprosis and cardiovascular disease in women with systemic lupus erythematosus. Arthritis Rheum, 2001,44 : 2338-2341.
  • 10[1]Rose CC,Lorraine AF.Vascular calcification[J].Curr Opin Nephrol Hypertens,1999,8:443-448.

共引文献47

同被引文献17

  • 1Takashi Ito, Stephen WS, Junichi A, et al. Thepotential usefulness of taurine on diabetes mellitus and its complications. Amino Acids, 2012, 42: 1529-1539.
  • 2. Saller A,Maggi S, Romanato G, et al. Diabetes and osteoporosis. Aging Clin Exp Res, 2008, 20: 280-289.
  • 3Hofbauer LG, Bruech CC, Singh SK, et al. Osteoporosis in patients with diabetes mellitus. J Bone Miner Res, 2007, 22:1317-1328.
  • 4Nicodemus KK, Folsom AR. Type 1 and 2 diabetes and incident hip fracture in postmenopausal women. Diabetes Care,2001, 24:1192-1197.
  • 5Duarte V M, Ramos AM, Rezende LA, et al. Osteopenia: a bone disorder associated with diabetes mellitus. Bone Miner Metab, 2005, 23:58-68.
  • 6Herrmann M, Seibel M. The amino and carboxyterminal cross-linked telopeptides of collagen type I ,NTX- I and CTX- I : a comparative review. Clinical Chimica Acta, 2008,393 .. 57-75.
  • 7Kanazawa I,Yamaguchi M, Yamamoto S, et al. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes meIlitus. Osteoporos Int, 2011, 22 187-194.
  • 8Cortizo AM, Sedlinsky C, McCarthy AD, et al. Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture. Eur J Pharmacol, 2006, 536:38-46.
  • 9. Kasai T, Bandow K, Suzuki H, et al. Osteoblast differentiation is functionally associated with decreased AMP kinase activity. Cell Physiol, 2009 740-749.
  • 10Grey A,Bolland M, Gamble G, et al. The peroxisome proliferator-aetivated receptor-gamma agonist resiglitazone decreases bone formation and bone mineral density in healthy postmenopansal women: a randomized,controlled trial. Clin Endoerinol Metab, 2007,92 : 1305-1310.

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中华老年医学杂志
2010年 第5期

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