摘要
目的:通过检测血小板参数MPV、D-二聚体及血清C-反应蛋白(CRP)水平,探讨其对溃疡性结肠炎(UC)的活动性的评价。方法:分别采用免疫扩散比浊法和自动血细胞分析系统分析及免疫比浊法检测65例活动期和36例缓解期溃疡性结肠炎患者及53位健康对照者的血小板参数MPV、D-二聚体及血清C-反应蛋白的水平及其间的关系,比较临床严重程度对MPV及D-二聚体及CRP的影响。结果:(1)、活动期溃疡性结肠炎患者平均血小板体积(MPV)明显低于缓解期患者及正常对照组(P<0.01),血清CRP及D-二聚体与缓解期患者及正常对照组相比明显增高(P<0.01),缓解期患者MPV较正常对照组也降低(P<0.05),缓解期CRP水平与对照组比较,差别有统计学意义(P<0.05),而D-二聚体水平与对照组比较,差别无统计学意义(P>0.05),(2)、重型UC患者MPV、CRP及D-二聚体水平与轻中型患者比较,差别有统计学意义(P<0.05)。结论:MPV、CRP及D-二聚体水平可作为溃疡性结肠炎(UC)的活动性的评定指标。
Objective：To investigate the value of serum Mean platelet volume（MPV）,C-reactive protein（CRP） and D-dipolymer in determination of disease activity and its severity of the patientswith ulcerative colitis（UC）.Methods：The contents of serum MPV,CRP and D-dipolymer of 65 UC sufferers at active stage,36 atremission stage,and 53 normal controls were conducted by full-automatic blood cell analyzer,latex-enhanced immunosuppressive turbidimetry and immunodiffusive turbidimetry respectively.To estimate the correlation of the severity of active ulcerative colitis（UC） with MPV,CRP and D-dipolymer.Results：（1） Mean platelet volume（MPV） was significatly decreased in patients with active UC compared with patients with remissive UC and healthy controls（P〈0.01）.The contents of serum CRP and D-dipolymer of the UC patients at active stage were remarkably higher than those of the other two groups（P〈0.01）.The content of CPR and MPV of the UC patients at remission stage was higher than that of the controls（P〈0.05）,while the content of D-dipolymer was not（P〈0.05）.（2） And compared with the UC patients ofmild and medium conditions the contents of MPV,serum CRP and D-dipolymer of the UC patients of serious condition showed significant difference（P〉0.05）.Conclusion：The levels of MPV,D-dipolymer and CRP can serve as useful indexes in the estimation of the activity and seriousness of UC.
出处
《中国卫生检验杂志》
CAS
2010年第5期1131-1132,1203,共3页
Chinese Journal of Health Laboratory Technology
