摘要
目的评价哌拉西林/舒巴坦对非发酵菌体外抗菌活性。方法采用微量肉汤稀释法测定哌拉西林/舒巴坦对细菌的体外抗菌作用。结果北京、天津、广州、哈尔滨和重庆5个城市的8家医院共收集菌株809株。对于所有铜绿假单胞菌,在8种测试药物中,哌拉西林/舒巴坦的敏感率最高(71.9%),而亚胺培南、头孢吡肟、头孢他啶、头孢哌酮/舒巴坦敏感率都低于50%。对于亚胺培南不敏感的铜绿假单胞菌,哌拉西林/舒巴坦敏感率仍可达55.8%。对于碳青霉烯敏感的鲍曼不动杆菌,哌拉西林/舒巴坦和头孢哌酮/舒巴坦敏感率最高,分别为71.0%和73.0%。对于嗜麦芽寡养单胞菌,26%和20%的菌株对哌拉西林/舒巴坦和哌拉西林/三唑巴坦的MIC≤16μg/mL。对于洋葱伯克霍尔德菌,69%的菌株对哌拉西林/舒巴坦的MIC≤16μg/mL。对于黄杆菌属和产碱杆菌属,哌拉西林/舒巴坦、头孢哌酮/舒巴坦和哌拉西林/三唑巴坦3种酶抑制剂复合制剂敏感率最高,分别为70.2%、63.2%、57.9%和94.4%、94.4%、91.7%。结论哌拉西林/舒巴坦对于多种非发酵菌具有良好的体外抗菌活性。对碳青霉烯不敏感的铜绿假单胞菌具备一定的抗菌优势,哌拉西林/舒巴坦是经验性治疗非发酵菌感染(包括复数菌感染)的的适宜选用药物之一。
Objective To evaluate the in vitro antimicrobial activity of piperacillin/sulbactam against clinical isolates of non-fermentative bacilli. Methods Antimicrobial susceptibility was tested by microbroth dilution. Results A total of 809 strains were collected from 8 hospitals in 5 cities, including Pseudomonas aeruginosa, ,4cinetobacter baumanniL Stenotrophomonas maltophilia, Burkholderia cepacia, Flavobacterium, and Alcaligenes. Compared with other β-lactams, Piperacillin/sulbactam displayed the highest activity against all the isolates of P. aeruginosa, especially for imipenem non-sensitive isolates, with the susceptibility rates of 71.9% and 55.8%, respectively. Piperacillin/sulbactam and cefoperazone/sulbactam kept good activity against imipenem sensitive isolates of A. baumannii, with the susceptibility rates of 71.0% and 73.0%, respectively. For the strains of Burkholderia cepacia, 69% strains exhibited MICs of ≤16μg/mL for Piperacillin/sulbactam. For the strains of Flavobacterium, and Alcaligenes, Piperacillin/sulbactam also had excellent activity, with the susceptibility rates of 70.2% and 94.4%, respectively. Conclusion Piperacillin/sulbactam exhibits good activity against non-fermentative bacilli, especial for imipenem-non-sensitive isolates of P. aeruginosa. Piperacillin/sulbactam is one of the appropriate drugs indicated for the empiric treatment ofmonomicrobial or polymicrobial infections caused by non-fermentative bacilli.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2010年第5期374-378,398,共6页
Chinese Journal of Antibiotics
关键词
哌拉西林/舒巴坦
非发酵菌
细菌药敏试验
最低抑菌浓度
Piperacillin/sulbactam
Non-fermentative bacilli
Antimicrobial susceptibility testing
Minimal inhibitory concentration
