摘要
非酒精性脂肪性肝病是一种遗传-环境-代谢应激相关性疾病。其发病机制尚未完全明确。其中肝细胞线粒体功能障碍对于非酒精性脂肪性肝病的发生发展起着关键作用。线粒体是肝细胞代谢所需能量的主要来源,其功能受损主要表现为线粒体膜流动性的下降,从而影响肝脏脂肪代谢,加重脂肪沉积,表现为非酒精性脂肪肝,进一步可发展为脂肪性肝炎甚至肝硬化。因此,有必要阐明线粒体膜流动性与非酒精性脂肪性肝病的关系,从而指导新的治疗方向。
Non-alcoholic fatty liver disease（NAFLD）is a genetic-environmental-metabolic stress related disease,with its pathogenesis not completely elucidated.There are consistent evidences that mitochondrial dysfunction plays a central role in it.Mitochondria are the mainly energy producer for liver metabolism.With Mitochondrial dysfunction,the fluidity of the mitochondrial membrane decreases,which lead to liver fat accumulation and disease progression to non-alcoholic steatohepatitis and liver cirrhosis.In this review we briefly recall the role of mitochondrial membrane fluidity in the pathophysiology of not-alcoholic fatty liver disease progression.
出处
《医学综述》
2010年第10期1447-1450,共4页
Medical Recapitulate
基金
国家自然科学基金(30600845)
关键词
非酒精性脂肪性肝病
肝细胞线粒体
膜流动性
Non-alcoholic fatty liver disease
Liver mitochondria
Membrane fluidity
