摘要
目的：观察吸入低浓度一氧化氮（ＮＯ）对高原肺水肿患者血流动力学的影响。方法：１２例高原肺水肿患者每人用ＢＧ９５１型一氧化氮治疗仪吸入０．００１％ＮＯ３０分钟作为治疗量，在吸入前、吸入中（１５分钟时）及治疗后分别用ＸＧⅢ型血液循环功能自动测试仪检测血流动力学指标。结果：高原肺水肿患者吸入ＮＯ即刻与治疗中比较总外周阻力〔（２２４．５７±８．５７）ｋＰａ·ｓ·Ｌ－１比（１２１．５７±４３．７２）ｋＰａ·ｓ·Ｌ－１〕、左心喷血阻抗〔（２３．３２±１．７２）ｋＰａ·ｓ·Ｌ－１比（１３．１５±２．９７）ｋＰａ·ｓ·Ｌ－１〕、全血粘度〔（７．０９±１．１０）ｍＰａ·ｓ比（４．４７±１．１０）ｍＰａ·ｓ〕、微循环半更新时间〔（１８．１３±１．４５）ｓ比（１３．９７±１．６６）ｓ〕及冠状动脉灌注压〔（１１．７６±１．５０）ｋＰａ比（１０．１８±１．３８）ｋＰａ，１ｋＰａ＝７．５ｍｍＨｇ〕降低非常明显（Ｐ＜０．００１或Ｐ＜０．０１），有效血容量〔（３．０７±０．６５）Ｌ比（５．６８±０．８０）Ｌ〕、每搏输出量〔（６３．８３±１３．９８）ｍｌ比（１０４．０２±１３．１１）ｍｌ〕增加非常显著（Ｐ均＜０．００１）。结论：ＮＯ对高原肺?
Objective:To observe the effect of low dose nitric oxide (NO) inhalation on hemodynamics in patients with pulmonary edema at high altitude.Methods:12 patients with high altitude pulmonary edema received 0 001% NO inhalation for 30 minutes by use of BG951 therapeutic equipment,and hemodynamics changes in those patients were determined prior to NO inhalation,15 minutes,and 30 minutes after treatment.Results:Following low dose NO inhalation,total peripheral resistance (TPR),AR,η,ALT and CCP were significantly decreased TPR:(224 57±8 57)kPa·s·L -1 vs.(121 57±43 72)kPa·s·L -1 ;AR:(23 32±1 72)kPa·s·L -1 vs.(13 15±2 97)kPa·s·L -1 ;η:(7 09±1 10)mPa·s vs.(4 47±1 10)mPa·s;ALT:(18 13±1 45)s vs.(13 97±1 66)s;CCP:(11 76±1 50)kPa vs.(10 18±1 38)kPa,1 kPa=7 5 mmHg, P <0 001 or P <0 01 ,while BV and SV were significantly increased BV:(3 07±0 65)L vs.(5 68±0 80)L;SV:(63 83±13 98)ml vs.(104 02±13 11)ml,both P <0 001).Conclusions:The NO inhalation has selective effect on pulmonary vascular dilation and improves cardiopulmonary function in patients with pulmonary edema at high altitude.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第2期90-91,共2页
Chinese Critical Care Medicine
基金
全军医药卫生科研基金
关键词
高原
肺水肿
一氧化氮
血流动力学
high altitude pulmonary edema\ \ nitric oxide\ \ hemodynamics
