摘要
目的观察奥拉西坦联合尼莫地平治疗血管性痴呆的临床疗效。方法将150例血管性痴呆患者随机分为3组,分别接受奥拉西坦治疗、尼莫地平治疗、奥拉西坦和尼莫地平联合治疗。治疗前后均运用简易智力状态检查量表(MMSE)积分法进行评价。结果 3周后奥拉西坦治疗组总有效率82.0%,联合治疗组总有效率92.0%,明显高于尼莫地平治疗组,各组治疗前后MMSE积分的变化有显著性差异(P<0.05),而联合用药组总有效率最高,MMSE积分的变化最明显,同时不良反应无明显增加。结论奥拉西坦是治疗血管性痴呆的有效药物之一,尼莫地平治疗对血管性痴呆也有一定的效果,两者联合使用能显著改善血管性痴呆患者的MMSE评分,临床疗效确切、安全。
Objective To observe the curative effect of Oxiracetam Injection combined with Nimodipine Tablets in treating the Vascular Dementiame.Methods 150 cases with Vascular Dementiame, were randomly assigned to 3 groups： Oxiracetam Injection group,Nimodipine Tablets group,Oxiracetam Injection combined with Nimodipine Tablets group.The MMSE scores were graded before and after treatment.Results After 3 weeks,the total effective rate of Oxiracetam Injection group and the total effective rate of Oxiracetam Injection combined with Nimodipine Tablets group were 82.0% and 92.0% separately,much higher than the Nimodipine Tablets group. In any group,the change of the MMSE scores before and after treatment was determined. In the group of treating with Oxiracetam Injection combined with Nimodipine Tablets,there was the higher total effective rate and more evident change of the MMSE scores than the other groups,and the side reaction didn’t improve obviously.Conclusion Oxiracetam Injection has effective therapy on the Vascular Dementiame,while Oxiracetam Injection combined with Nimodipine Tablets has the synergistic effect, and the clinic efficacy is definite and safe.
出处
《中国实用医药》
2010年第15期45-46,共2页
China Practical Medicine
