摘要
目的研究ｂｃｌ－２、ｃ－ｅｒｂＢ－２、ｐ５３蛋白表达在胃癌发生中的作用。方法免疫组织化学方法。结果ｂｃｌ－２、ｃ－ｅｒｂＢ－２、ｐ５３蛋白表达阳性率分别为６０％、２２％和３８％。３种蛋白表达之间无显著相关性，且与胃癌临床病理参数亦无显著相关性。肠化组织ｂｃｌ－２表达阳性率为５３．３％。结论三种蛋白在胃癌的发生中可能起重要作用。
Otjective To study the roles of expression of bcl 2、c erbB 2 and p53 protein in the carcinogenesis of gastric cancer(GC).Methods The immunohistochemical technique was used. Results bcl 2、c erbB 2 and p53 protein were stained in 30/50(60%) ,11/50 (22%)and 19/50(38%) of GC respectively. No significant correlation was found among the expression of bcl 1、c erbB 2 and p53,and between the expression of bcl 2、c erbB 2 and p53 protein and clinicopathological variables of GC.The bcl 2 protein was detected in 8/15(53.3%) of intestinal metaplasia.Conclusions The results suggested that the expression of bcl 2,C erbB 2 and p53 protein may play an important role in the carcinogenesis of GC and bcl 2 may be a useful marker in predicting the changes from intestinal metaplasia to GC.
出处
《肿瘤研究与临床》
CAS
1999年第1期9-10,共2页
Cancer Research and Clinic
