摘要
目的为评价人群大肠癌风险,用Meta分析方法对大肠癌的主要危险因素家族史、饮食习惯、肠息肉史、慢性腹泻、慢性便秘和黏液血便的综合危险度进行文献综合,并建立综合评价模型。材料和方法在PubMed和CBMdisc电子数据库中检索,并通过电子检索和手工查阅的方式获得符合纳入标准的文章共50篇进行Meta分析,计算各因素的合并效应综合危险度值。结果家族史、多吃肉类、多吃腌制食品、少吃蔬菜和少吃水果的综合危险度值分别为1.91、1.37、1.60、1.51、1.23;肠息肉史、慢性腹泻、慢性便秘和黏液血便的综合危险度值分别为18.00、4.24、2.12和16.50。结论结合多种危险因素的风险模型可以根据社区个体的大肠癌家族史、饮食习惯和疾病史等评估患大肠癌的风险,据此给予个性化的筛查方案;在大肠癌高风险人群中进行筛查,将大大提高大肠癌早期诊治的效率和成本效果。
Objective To evaluate individual risk for colorectal cancer,we used method of meta-analysis to calculate OR of the main risk factors of colorectal cancer-family history of colorectal cancer,eating habits,history of intestinal polypus,chronic diarrhea,chronic constipation and mucosal stool or hematochezia,and then built a risk evaluation model.Methods Published papers were searched in PubMed and CBMdisc related to the above risk factors and 50 papers were got which fit enroll-standard,calculated OR for each factor.Results OR of family history of colorectal cancer,consuming much meat and salty food,but little vegetable and fruit,history of intestinal polypus,chronic diarrhea,chronic constipation and mucosal stool or hematochezia were 1.91,1.37,1.60,1.51,1.23,18.00,4.24,2.12,and 16.50.Conclusion The risk evaluation model can evaluate one person in high risk or not for colorectal cancer according to his family history,disease history,symptoms and living habits and then we can give suitable screen suggestion to him.If we screen colorectal cancer in high risk people we can lower the cost for colorectal cancer screen.
出处
《循证医学》
CSCD
2010年第2期86-91,97,共7页
The Journal of Evidence-Based Medicine
关键词
大肠肿瘤
家族史
饮食习惯
肠息肉
症状
Meta分析
风险评价
colorectal neoplasms
family history
eating habits
intestinal polypus
symptom
meta-analysis
risk evaluation
