摘要
目的:观察盐酸环喷托酯、托吡卡胺、硫酸阿托品3种眼用制剂局部点眼后的疗效及不良反应(ADR)。方法:对600例弱视儿童患者按就诊顺序分为3组,每组200例,分别使用1%托吡卡胺滴眼液、1%硫酸阿托品眼用凝胶、1%盐酸环喷托酯滴眼液,观察3组散瞳效果,记录检影结果及患者发生眼部及全身ADR情况。结果:托吡卡胺组眼部及全身ADR均低于硫酸阿托品组及盐酸环喷托酯组(P<0.05),但睫状肌麻痹效果不够充分;盐酸环喷托酯组眼局部及全身ADR均低于硫酸阿托品组(P<0.05),睫状肌麻痹效果与阿托品相当。结论:盐酸环喷托酯睫状肌麻痹完全,散瞳效果好,起效快,持续时间短,ADR低。
OBJECTIVE：To study clinical efficacy and adverse drug reaction（ADR） of Cyclopentolate hydrochloride eye drops,Tropicamide eye drops and Atropine eye drops.METHODS：600 asthenopic children were divided into 3 groups according to visiting time sequence（n=200）.3 groups were treated with 1% Cyclopentolate hydrochloride eye drops,1% Tropicamide eye drops and 1% Atropine eye drops respectively.Mydriasis effects of 3 groups were observed and results of retinoscopy were recorded.Ocular ADR and systemic ADR were surveyed.RESULTS：The level of ocular ADR and systemic ADR of tropicamide group were lower than other 2 groups（P0.05）,but the palsy effect of ciliary muscle was inadequate.The level of ocular ADR and systemic ADR of cyclopentolate hydrochloride group were lower than that of atropine sulfate group（P0.05）,the palsy effect of cyclopentolate hydrochloride on ciliary muscle corresponded with atropine.CONCLUSION：Cyclopentolate hydrochloride has the characteristics of complete palsy of ciliary muscle,sound mydriasis effects,rapid onset,short duration and faint ADR.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第20期1876-1878,共3页
China Pharmacy
