摘要
目的:观察西咪替丁治疗慢性肺心病失代偿期的其他效应。方法:72例慢性肺心病失代偿期的患者随机分为治疗组、对照组,各36例。对照组给予常规治疗,治疗组在对照组的基础上加用西咪替丁,静脉滴注,疗程48h。观察2组治疗前、后呼吸频率、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、摄取主食数量、血清电解质(K+、Na+、Cl-)的变化。结果:治疗组治疗后呼吸频率变慢,PaO2升高,PaCO2下降,摄取主食数量增加,血清电解质紊乱减轻,与对照组比较有显著性差异(P<0.05)。结论:西咪替丁对慢性肺心病失代偿期具有减轻呼吸困难、纠正缺氧和二氧化碳潴留、改善饮食、调整血清电解质紊乱等功效。
OBJECTIVE：To observe the other effects of cimetidine in the decompensated stage of chronic cardiopulmonary disease. METHODS： 72 patients with uncompensated chronic cardiopulmonary disease were assigned into therapy group and control group （n=36）. Both groups were given routine treatment. Therapy group were additionally treated with cimetidine intravenously for 48 h. The changes of respiration frequency, arterial partial pressure of oxygen （PaO2）, arterial partial pressure of carbon dioxide （PaCO2）, intake of staple food and electrolytes in blood serum of 2 groups before and after treatment were determined. RESULTS：In therapy group, the respiration frequency, the level of PaCO2 and disorder of electrolytes in blood serum were decreased and the level of PaO2 and intake of staple food were increased. Above items of therapy group were all different from that of control group （P0.05）. CONCLUSION： Cimetidine shows effect roles in the decompensated stage of chronic cardiopulmonary disease such as relieving dyspnea, regulating anoxia and carbon dioxide retention, improving diet and adjusting electrolyte disturbances in blood serum.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第20期1858-1859,共2页
China Pharmacy
关键词
西咪替丁
慢性肺心病
失代偿期
消化道出血
Cimetidine
Chronic cardiopulmonary disease
Decompensated stage
Gastrointestinal bleeding
