摘要
为研究榼藤子[Entada phaseoloides(L.)Merr.]种仁的化学成分,利用正反相硅胶柱色谱、制备HPLC分离纯化,通过现代波谱学技术鉴定结构。从70%乙醇提取物的正丁醇萃取部位分离得到4个含硫酰胺类化合物,分别为entadamideA-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside(1)、entadamideA(2)、entadamideA-β-D-glucopyranoside(3)和clinacosideC(4)。化合物1为新化合物,化合物4为首次从该属中分离得到。
To study the chemical constituents of the Entada phaseoloides （L.） Merr.,seeds of Entada phaseoloides were extracted with 70% ethanol at room temperature.Isolation and purification were performed by silica gel,reversed-phase silica gel column chromatography and semi-preparative HPLC.Structures of the pure compounds were established on the basis of spectral analysis.Four sulfur-containing amide compounds were isolated from the n-BuOH-soluble fraction and identified as entadamide A-β-D-glucopyranosyl-（1→3）-β-D-glucopyranoside （1）,entadamide A （2）,entadamide A-β-D-glucopyranoside （3） and clinacoside C （4）.Compound 1 is a new compound.Compound 4 is isolated from the genus Entada for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第5期624-626,共3页
Acta Pharmaceutica Sinica
基金
Project supported by the 11th Five-year Plan of Ministry of Science and Technology of the People's Republic of China (No.2007BAI48B08)
关键词
榼藤子
化学成分
含硫酰胺
Entada phaseoloides
chemical constituent
sulfur-containing amide
