摘要
目的:探讨儿童传染性单核细胞增多症(IM)不同时期血清细胞因子TNF-α、IL-18水平的变化。方法:选择2007-06/2009-06湖南省儿童医院收治的IM患儿72例为观察组,并随机选择同期健康儿童30例作为对照组。在病程急性期、病程1、3、6个月分别采集观察组患儿外周静脉血,健康对照组以同样方法采集静脉血,采用RIA检测TNF-α和ELISA检测IL-18水平。结果:观察组患儿IM急性期血清中TNF-α和IL-18含量均明显高于对照组(P<0.05),随病程时间推移,TNF-α和IL-18含量呈逐渐下降趋势,但各个病程时间点TNF-α和IL-18含量仍明显高于对照组(P<0.05)。观察组中45例轻症IM患儿与27例重症IM患儿相比较,重症IM患儿TNF-α,IL-18水平高于轻症IM患儿,两者比较有统计学差异(P<0.05)。结论:血清TNF-α和IL-18水平动态变化是判断IM患儿免疫状态和评估预后的重要指标。
AIM：To study the dynamic changes of levels of serum interleukin-18（IL-18）and tumor necrosis factorα（TNF-α）in children with infectious mononucleosis（IM）.METHODS：72 patients with IM were analyzed the expression of TNF-α and IL-18 by RIA and ELISA respectively in acute phase,convalescent phase（the first month,the third month,the sixth month）and the control group.RESULTS：The levels of serum TNF-α and IL-18 in patients with IM were significantly higher than that in control（P0.05）.The Serum levels of TNF-α and IL-18 decreased with time and in patients at stage were significantly higher than that in control（P0.05）.The levels of serum cytokine were correlated with the state of illness.CONCLUSION：The serum cytokine TNF-α and IL-18 may be regarded as index to reflect the state of immunity and prognosis of patients with IM.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2010年第5期480-481,共2页
Chinese Journal of Cellular and Molecular Immunology
基金
重庆市自然科学基金资助项目(CSTC2006EB5030)
